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Example sentences for: multimers
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The claim that such turbidity did not affect 13C-NMR measurements [ 3 5 6 ] contrasts with evidence that even small multimers can change NMR chemical shifts [ 25 26 ] . It should be noted also that, at high concentrations of B =, extensive, reversible self-association of B =can lead to apparently stable supersaturation with no separation of an insoluble phase [ 2 ] . For example, at pH 8.5 and a UCB concentration of 20 μM (63 times S), the weight-average aggregation number of UCB has been found to be 7.17 [ 18 ] , corresponding to a molecular weight of 4,195.
A previous study has reported that the presence of capsaicin and chemical cross-linkers influence the formation of multimers in VR1 [ 23 ] . Moreover, this study reported that cross-linking could be a Ca 2+mediated process, through the activation of endogenous transglutaminases.
For those ion channels within this superfamily for which stoichiometry has been directly examined, all have been shown to be composed of four six-transmembrane domain subunits or pseudosubunits, with auxiliary subunits sometimes present as well [ 22 ] . An initial characterization of VR1 channels expressed in Cos and CHO cells has recently revealed that, under certain conditions, they run as multimers on pseudo-native (PFO) gels, with tetramers being one of the primary bands observed [ 23 ] . Thus, like other six membrane spanning domain channels, VR1 almost certainly forms as a tetramer; whether it combines with homologous subunits to form heteromeric channels remains to be determined.
The higher MW bands most likely represent GFAP multimers, while the lower MW bands are possibly degradation products.
Evidence that VR1 is capable of forming multimers has been previously reported when studied under pseudo-native conditions [ 23 ] . In this previous study, tetramers were the major band observed, although larger and smaller bands were also seen.
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