Words similar to multifactorial
Example sentences for: multifactorial
How can you use “multifactorial” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, the binding sites for Mcm1p and Rap1p are poorly modeled by exact words, in that these transcription factors bind sequences with relaxed specificity at certain positions [ 11 ] . Our method missed examples of multifactorial regulation involving Mcm1p or Rap1p that were suggested by previous work using position-weight matrices [ 17 ] . In addition, our method required sequence identity for a word to be labeled as conserved.
In yeast and most other eukaryotes, the transcriptional regulation of individual genes is often multifactorial, as multiple transcription factors may bind to a single TCR [ 1 2 ] . Multifactorial regulation encompasses several distinct biochemical mechanisms.
In some cases, transcription factors may bind cooperatively to adjacent DNA sites via direct physical interaction [ 3 4 ] . In other cases, multiple transcription factors that bind independently may recruit a common co-activator [ 5 ] , or may act independently of one another to alter gene expression in response to distinct cellular cues [ 6 ] . Recent studies have also suggested that nearby transcription factors may collaboratively compete with nucleosomes, thus enhancing the binding of individual transcription factors [ 7 8 ] . Many experiments in yeast have shown that specific pairs of factors must be bound near each other for multifactorial regulation to occur [ 7 8 9 10 ] , and it is on these spatial constraints that we focus here.
The etiology of PFD is probably multifactorial, including a genetic predisposition to connective tissue abnormalities, vaginal childbirth with damage to the innervation of the pelvic floor muscles, estrogen deficiency, and aging effects [ 1 ] . The pelvic floor, situated at the bottom of the abdominal cavity, forms a supporting shelf for the abdominal and pelvic viscera.
Although the exact details concerning the cause of compaction remain unknown, some features of the multifactorial process are understood.
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