Words similar to multifactorial
Example sentences for: multifactorial
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Low postpartum estrogen levels as well as increased peripartum testosterone levels have been associated with increased depressive and anger symptoms [ 6 7 ] . Even lower levels of cholesterol have been linked with symptoms of anxiety, anger, hostility, and depression in the postpartum period [ 8 ] . As the diversity of implicated risk factors suggests, postpartum mood disorders, like many psychiatric entities, most likely have a multifactorial etiology which has not been well delineated.
The etiology of PFD is probably multifactorial, including a genetic predisposition to connective tissue abnormalities, vaginal childbirth with damage to the innervation of the pelvic floor muscles, estrogen deficiency, and aging effects [ 1 ] . The pelvic floor, situated at the bottom of the abdominal cavity, forms a supporting shelf for the abdominal and pelvic viscera.
The inheritance patterns of FIA have not been determined, partly because IA is a late age-at-onset disease and partly because it is likely to be a multifactorial disease for which simple Mendelian models will not fit well [ 1 21 22 23 ] .
In yeast and most other eukaryotes, the transcriptional regulation of individual genes is often multifactorial, as multiple transcription factors may bind to a single TCR [ 1 2 ] . Multifactorial regulation encompasses several distinct biochemical mechanisms.
In some cases, transcription factors may bind cooperatively to adjacent DNA sites via direct physical interaction [ 3 4 ] . In other cases, multiple transcription factors that bind independently may recruit a common co-activator [ 5 ] , or may act independently of one another to alter gene expression in response to distinct cellular cues [ 6 ] . Recent studies have also suggested that nearby transcription factors may collaboratively compete with nucleosomes, thus enhancing the binding of individual transcription factors [ 7 8 ] . Many experiments in yeast have shown that specific pairs of factors must be bound near each other for multifactorial regulation to occur [ 7 8 9 10 ] , and it is on these spatial constraints that we focus here.
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