Words similar to multifactorial
Example sentences for: multifactorial
How can you use “multifactorial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because transcription factors participating in multifactorial regulation may require binding sites in physical proximity to each other, we searched for groups of conserved sequences that were more closely spaced in TCRs than expected.
The inheritance patterns of FIA have not been determined, partly because IA is a late age-at-onset disease and partly because it is likely to be a multifactorial disease for which simple Mendelian models will not fit well [ 1 21 22 23 ] .
The Msn2/4p and Hsf1p transcription factors, whose binding sites were similar to words identified in a template, represent an example of multifactorial regulation in response to distinct environmental stimuli [ 6 ] . Spacing constraints between their binding sites could nevertheless be important under conditions when both factors are active.
For example, the binding sites for Mcm1p and Rap1p are poorly modeled by exact words, in that these transcription factors bind sequences with relaxed specificity at certain positions [ 11 ] . Our method missed examples of multifactorial regulation involving Mcm1p or Rap1p that were suggested by previous work using position-weight matrices [ 17 ] . In addition, our method required sequence identity for a word to be labeled as conserved.
In some cases, transcription factors may bind cooperatively to adjacent DNA sites via direct physical interaction [ 3 4 ] . In other cases, multiple transcription factors that bind independently may recruit a common co-activator [ 5 ] , or may act independently of one another to alter gene expression in response to distinct cellular cues [ 6 ] . Recent studies have also suggested that nearby transcription factors may collaboratively compete with nucleosomes, thus enhancing the binding of individual transcription factors [ 7 8 ] . Many experiments in yeast have shown that specific pairs of factors must be bound near each other for multifactorial regulation to occur [ 7 8 9 10 ] , and it is on these spatial constraints that we focus here.
Loading...