Words similar to multidomain
- multicultural
- multiculturalism
- multiculturalists
- multiculturally
- multidialectal
- multidimensional
- multidimensionalsearch
- multidirectionally
- multidisciplinary
- multidomain
- multidomestic
- multidrug
- multidrug-resistance
- multidrug-resistant
- multiecho
- multiexponential
- multifaceted
- multifactorial
- multilateral
- multilingual
Example sentences for: multidomain
How can you use “multidomain” in a sentence? Here are some example sentences to help you improve your vocabulary:
TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .
Typically, these domains were identified in multidomain proteins that additionally contained several previously undetected, evolutionarily mobile domains occurring in different contexts.
The majority of the domains with which the KilA-N and Bro-N domains combine in multidomain proteins are restricted to proteins encoded by temperate bacteriophages and large eukaryotic DNA viruses (the exceptions are a few domains that are common in cellular proteomes, such as HTH, CCCH and RING finger).
This information is represented as a directed graph in Figure 2b, in which each vertex corresponds to a particular domain and the edges connect domains that combine to form multidomain proteins.
The region of structural similarity shared by the catalytic domain of the β' subunit of the DDRPs and the above proteins corresponds to a distinct globular fold known as the double-psi beta-barrel (DPBB) [ 62 63 64 ] . The SCOP database included the RNA polymerase subunits in the multidomain protein class but mentions the presence of a DPBB domain in each of the β and β' subunits ( [ 65 ] ; see below).
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