Words similar to mtx-induced

Example sentences for: mtx-induced

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These results suggest that inhibition of MTX-induced change in [Ca 2+] i prevents or attenuates both the activation of COP and cytolysis.
As previously reported [ 3 ] , MTX-induced uptake of ethidium in BAECs was biphasic in the absence of the U-compounds (Fig 1, lower panel ). The first phase, which extends for ~5 min after addition of MTX, reflects the activation of COP, whereas the second phase is temporally associated with LDH release and thus reflects cell lysis [ 3 ] . Addition of either U73122 or U73343, ~3 min before MTX, produced an inhibition of ethidium uptake (Fig 1, lower panel ). Both phases of ethidium uptake were attenuated by the U-compounds and U73343 again appeared to have a greater potency compared to U73122.
We previously showed that MTX-induced activation of COP allows leakage of fura-2 from human skin fibroblasts [ 8].
The same experimental protocol was employed for evaluation of ethidium uptake (Fig 3, lower panel ). Again, MTX-induced uptake of ethidium was biphasic in the absence of U73343 ( trace a ). Addition of the U-compound shortly after MTX (i.e.
LDH release, indicative of the final phase of MTX-induced cell death, is associated with massive bleb dilation.