Words similar to mtx-induced
Example sentences for: mtx-induced
How can you use “mtx-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although elevating [Ca 2+] i with ionomycin had no effect on vital dye uptake, preliminary experiments in which fibroblasts were loaded intracellularly with the Ca 2+chelator BAPTA, showed that MTX-induced responses were significantly delayed, suggesting that a rise in [Ca 2+] i is necessary, but not sufficient for MTX-induced COP formation.
We previously showed that MTX-induced activation of COP allows leakage of fura-2 from human skin fibroblasts [ 8].
It is important to note that these MTX-induced events are only observed in the presence of U73343 and occur in the absence of a measurable rise in [Ca 2+] i . To our knowledge, this is the first evidence that MTX has effects independent of a rise in [Ca 2+] i . Perhaps more importantly, the results of the present study suggest that U73343 converts MTX-induced oncosis into apoptosis and that a rise in [Ca 2+] i is necessary for oncotic cell death.
LDH release, indicative of the final phase of MTX-induced cell death, is associated with massive bleb dilation.
As previously reported [ 3 ] , MTX-induced uptake of ethidium in BAECs was biphasic in the absence of the U-compounds (Fig 1, lower panel ). The first phase, which extends for ~5 min after addition of MTX, reflects the activation of COP, whereas the second phase is temporally associated with LDH release and thus reflects cell lysis [ 3 ] . Addition of either U73122 or U73343, ~3 min before MTX, produced an inhibition of ethidium uptake (Fig 1, lower panel ). Both phases of ethidium uptake were attenuated by the U-compounds and U73343 again appeared to have a greater potency compared to U73122.
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