Words similar to mtx

Example sentences for: mtx

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These results suggest that U73343 is able to rapidly block both the MTX-induced change in [Ca 2+] i and COP formation when added shortly after MTX.
As previously reported [ 3 ] , MTX-induced uptake of ethidium in BAECs was biphasic in the absence of the U-compounds (Fig 1, lower panel ). The first phase, which extends for ~5 min after addition of MTX, reflects the activation of COP, whereas the second phase is temporally associated with LDH release and thus reflects cell lysis [ 3 ] . Addition of either U73122 or U73343, ~3 min before MTX, produced an inhibition of ethidium uptake (Fig 1, lower panel ). Both phases of ethidium uptake were attenuated by the U-compounds and U73343 again appeared to have a greater potency compared to U73122.
MTX (0.
Stimulation of P2X purinergic receptors by ATP causes similar changes in cytosolic Ca 2+and vital dye uptake [ 10, 11, 12, 13, 14, 15, 16, 17] suggesting that MTX activates a cell death cascade that is physiologically relevant, although the exact role of either the P2X- or MTX-induced cascade in normal cellular biology remains unknown.
It is however, well established that MTX causes the hydrolysis of phosphoinositides in some cell types, presumably via activation of phospholipase C (PLC) [ 12 13 ] . Activation of PLC by MTX appears to be indirect resulting as a consequence of increased [Ca 2+] i . These results suggest that PLC may be involved in activation of COP and/or in the cytolysis phase of MTX action.