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Example sentences for: molegos

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Finding APE molegos in the DNase 1 superfamily
The first two β-strand molegos in synaptojanin are 2 residues longer than in APE or DNase 1. By regarding these elements as simple lego style blocks, and recognizing the connectivity, molego based alignment correctly defined the changing length of the secondary structure elements.
Although DNase 1 has only 18% overall sequence identity and the IPP domain of synaptojanin, 14%, to APE1, we could show that most of the areas of identity were in molegos common to all three proteins.
These molegos could in turn be functionally annotated by comparing the DNA binding profile of APE1 with that of the less specific nuclease DNase 1. This analysis indicated that residues binding 3' to the site of phosphorolytic cleavage control the substrate specificity of APE1.
Molegos may prove useful in to check alignments for template based modeling of homologues with low identity (Table 2and Figure 7), if the "anchoring" residues are conserved in sequence or property across the members of both subfamilies.