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Example sentences for: molegos

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We then demonstrated that the shared molegos served a similar role in substrate binding by comparing the DNA binding profile of huAPE1 with that for the less specific enzyme DNase 1. The molegos present in both enzymes interact with target DNA in a similar fashion, while residues in molegos distinctive for APE1 control specificity by binding primarily to the bases around the apurinic site.
The extensive contacts that APE1 makes to these positions are mediated by molegos it does not share with DNase 1. Molegos 6, 7a and 10 all have residues within hydrogen bonding distance of the three basepairs 3' of the AP-site.
Matching of molegos, guided by the degree of conservation of individual residues across the three families, allowed a better alignment of the individual secondary structure elements among the proteins than DALI achieved.
Molegos may prove useful in to check alignments for template based modeling of homologues with low identity (Table 2and Figure 7), if the "anchoring" residues are conserved in sequence or property across the members of both subfamilies.
These results indicate that molegos can provide a useful basis for identifying specificity determining regions in enzymes with similar active sites but different activity spectra [ 46 28 3 ] . Site directed mutagenesis based on these results can define the function of the unique elements of the APEs, and aid in the design of enzymes with altered specificity.