Words similar to molego

Example sentences for: molego

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An alanine substitution mutant, N226A, of a conserved residue at the end of molego 7a that forms a hydrogen bond with the second phosphate group downstream of the abasic site, had enhanced APE activity but increased Km and Kd values, similar to an alanine mutant of R177, which binds to the same site, reported previously [ 34 ] . A combination of the two mutants, N226A and R177A, substantially reduced the ability of APE1 to bind to DNA containing an abasic site (Izumi et al.
Another potential area for applying the molego approach is in homology modeling.
The first two β-strand molegos in synaptojanin are 2 residues longer than in APE or DNase 1. By regarding these elements as simple lego style blocks, and recognizing the connectivity, molego based alignment correctly defined the changing length of the secondary structure elements.
The longest molego, 7, was broken down into two areas, with the contiguous region labeled 7a.
This word based, sequence (motif) to structure (molego) to function method has clear implications for genomic analysis and template based homology modeling, as well as immediate application in recognizing specificity determinants in proteins that share active sites common to many enzymes [ 28 ] .