Words similar to molego

Example sentences for: molego

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The drawings of "molego blocks" and structures (Figures 2, 3, 4and 7), contact plots of protein/DNA (Figures 5, 6), and calculation of the RMSD between similar segments (Table 2) were done with MOLMOL http://www.mol.biol.ethz.ch/wuthrich/software/molmol/ [ 52 ] . The RMSD values in Table 1were calculated using SwissPDB viewer and the "fit selected residues" option.
An alanine substitution mutant, N226A, of a conserved residue at the end of molego 7a that forms a hydrogen bond with the second phosphate group downstream of the abasic site, had enhanced APE activity but increased Km and Kd values, similar to an alanine mutant of R177, which binds to the same site, reported previously [ 34 ] . A combination of the two mutants, N226A and R177A, substantially reduced the ability of APE1 to bind to DNA containing an abasic site (Izumi et al.
Molego building and comparison
Another potential area for applying the molego approach is in homology modeling.
The first two β-strand molegos in synaptojanin are 2 residues longer than in APE or DNase 1. By regarding these elements as simple lego style blocks, and recognizing the connectivity, molego based alignment correctly defined the changing length of the secondary structure elements.