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Example sentences for: mll
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In terms of conserved gene neighborhoods, CYTH-domain-encoding genes, like mll4592 from α-proteobacteria, are frequently found in the neighborhood of genes encoding solo CHADs (Fig.
For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
Consistent with this, several proteins, such as mll3685 from Mesorhizobium loti, have duplications or triplications of this region, which indicate that the boundaries of each repeat correspond perfectly to the β-barrel unit of PRC-H.
The hits included sequence matching DNA regions located within or close to mobile genetic elements, including the diversity (D) gene segments of the variable region of the immunoglobulin (Ig) heavy chain [ 35 ] , and break points of chromosomal translocation between Ig DH2-2 and the B cell lymphoma 1 BCL-1 gene [ 36 ] , and between the ENL/MLLT1/LTG19 gene and myeloid lymphoid leukemia MLL gene [ 37 ] .
Reciprocal searches initiated with the E. coli YgiF protein (residues 1-200), not only recovered its bacterial orthologs, archaeal CyaB homologs and eukaryotic proteins, but also several others such as Bacillus subtilis YjbK, Methanosarcina Ma2350, and Mesorhizobium loti Mll4592 with e-values in the range of 10 -4-10 -6upon first detection.
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