Words similar to mlh

Example sentences for: mlh

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Aberrant promoter methylation changes that occur in cancer are associated with transcriptional repression and loss of function of the gene by interrupting the binding of proteins involved in transcription activator complex [ 12 ] . Our gene expression analysis by RT-PCR demonstrated that all tumors that showed methylation of MGMT and MLH1 also showed down-regulated expression, while RASSF1A and RARB genes showed down-regulation of mRNA levels in most of the methylated tumors.
The promoters of CDKN2A , MGMT , BRCA1 , TP73 , TIMP3 , GSTP1 , and MLH1 genes were rarely (<10% cases) methylated.
The primers used for amplification of methylated and unmethylated promoters of genes RARB , TIMP3 , CDKN2A , p14 ARF , MGMT , DAPK , CDH1 , GSTP1 , APC promoter 1A, RB1 , MLH1 , TP73 , BRCA1 , FHIT , and HIC1 have been described previously http://pathology2.jhu.edu/pancreas/prim0425.htm#MSP; [ 32 47 48 49 ] . Methylated (MF and MR) and unmethylated (UF and UR) primers for RASSF1A promoter were designed according to Herman et al [ 46 ] and as described earlier [ 50 ] . PCR products were run on 2% agarose gels and visualized after ethidium bromide staining.
Eight genes ( MGMT , RASSF1A , BRCA1 , APC , RARB , CDH1 , MLH1 , and TIMP3 ) that exhibited methylation in >3% of the cases were examined (Fig.
1%; RASSF1A , 10%; APC , 10%; CDKN2A , 8.9%; MGMT , 6.7%; BRCA1 , 5.6%; TP73 , 2.2%; TIMP3 , 1.1%; GSTP1 , 1.1%; and MLH1 , 1.1% (Table 1).