Words similar to mlh

Example sentences for: mlh

How can you use “mlh” in a sentence? Here are some example sentences to help you improve your vocabulary:

We examined the status of promoter hypermethylation of 16 genes ( CDH1 , DAPK , RARB , HIC1 , FHIT , RASSF1A , APC , CDKN2A , MGMT , BRCA1 , TP73 , TIMP3 , GSTP1 , MLH1 , p14 ARF , and RB1 ) in eight specimens of normal cervical squamous epithelia and 90 CC specimens.
1%; RASSF1A , 10%; APC , 10%; CDKN2A , 8.9%; MGMT , 6.7%; BRCA1 , 5.6%; TP73 , 2.2%; TIMP3 , 1.1%; GSTP1 , 1.1%; and MLH1 , 1.1% (Table 1).
Aberrant promoter methylation changes that occur in cancer are associated with transcriptional repression and loss of function of the gene by interrupting the binding of proteins involved in transcription activator complex [ 12 ] . Our gene expression analysis by RT-PCR demonstrated that all tumors that showed methylation of MGMT and MLH1 also showed down-regulated expression, while RASSF1A and RARB genes showed down-regulation of mRNA levels in most of the methylated tumors.
To examine the biological role of promoter methylation in CC, we assessed the levels of mRNA by semi-quantitative RT-PCR in eight cell lines and compared with the respective control values obtained from the averages calculated from 2 normal cervix after normalization against ACTB . This analysis was performed on 7 genes ( CDH1 , DAPK , RARB , HIC1 , MGMT , RASSF1A , and MLH1 ) that exhibited methylation in one or more cell lines and primary tumors (Fig.
MLH1 gene was methylated in one cell line (SW756) but we found no evidence of down-regulated expression in this cell line (data not shown).