Words similar to mispairing
Example sentences for: mispairing
How can you use “mispairing” in a sentence? Here are some example sentences to help you improve your vocabulary:
Oxoguanine has become the benchmark for oxidative DNA modifications; it is arguably the most important mutagenic lesion in DNA (mispairing with adenine during chromosomal replications causes GC → TA transversions) [ 24 ] . It is suggested that untoward oxidative stresses to DNA prompt cell-cycle delay, antiapoptotic, and repair responses.
Comparative genomic analysis and cloning expression showed that the length of the polyG tract of pmpG 10 varies between strains and within an isolate [ 12 13 ] . Furthermore, variation of the length of polyG has been demonstrated that it plays a role in the differential expression of PmpG 10 [ 12 ] . Variability in short nucleotide repeats generated via slipped strand mispairing are key elements in the generation of phenotypic diversity within many pathogenic microorganisms [ 18 ] . Further investigation will be required to determine if the expression of members of the Cpn 1054 gene family is affected by the observed variability in length of the polyC tract.
The formation of these cytogenetic abnormalities is mediated by low-copy repeated sequences, or duplicons [ 1 ] . High sequence homology between copies presumably facilitates mispairing and unequal recombination events in meiosis.
These VNTRs have been observed throughout the prokaryotic and eukaryotic kingdoms [ 14 15 ] . The addition or deletion of repeat units within a locus is believed to be caused by slipped-strand nucleotide mispairing, and/or unequal crossover events which increase the rate of mutation at these loci [ 16 ] . The variations in the number of repeats give rise to molecular alleles for a given locus and aid in the characterization of the individual.
Slip-strand mispairing is believed to be an important factor in generating tandem repeat polymorphisms [ 16 ] . Misalignment of DNA strands during chromosome replication is thought to lead to the addition or deletion of repeat units.
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