Words similar to mislocalization

Example sentences for: mislocalization

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Finally, the encoded proteins are associated with distinct NPC subcomplexes [ 2 ] , and we speculated that true mislocalization mutants would require disruption of both sets of subcomplexes and more likely reflect defects in global NPC structure and assembly.
The discrepancy between our findings and findings of nuclear localization of TTP may be due to several factors [ 20 21 22 24 25 ] . First, most of those studies did not measure endogenous TTP but usually relied on transfection of cell lines, perhaps resulting in mislocalization due to the presence of an epitope tag or overexpression [ 20 21 22 24 25 ] . Second, by definition, those cells were largely cycling and thus were not representative of normal hematopoietic cells.
This strategy was based on the ability to functionally express GFP-nucleoporin fusions, and the assumption that NPC a ssembly/mislocalization mutants expressing a GFP-nucleoporin would have distinct fluorescence properties [ 26 ] . In wild type yeast cells, fluorescence microscopy localization of proteins at NPCs appears as punctate staining of virtually the entire nuclear rim circumference (see Figure 2).
However, when the genes encoding GFP-tagged Nups were crossed into these mutant backgrounds, all displayed GFP-Nup mislocalization under non-permissive conditions (Figure 7and data not shown).
The mutants displaying the strongest GFP-Nup mislocalization phenotypes were backcrossed.