Words similar to mislocalization
Example sentences for: mislocalization
How can you use “mislocalization” in a sentence? Here are some example sentences to help you improve your vocabulary:
Given that the formation of the extensive membrane networks in the sec13 and sec23 mutants was coincident with the GFP-Nup mislocalization, we favor one of the two indirect models.
The discrepancy between our findings and findings of nuclear localization of TTP may be due to several factors [ 20 21 22 24 25 ] . First, most of those studies did not measure endogenous TTP but usually relied on transfection of cell lines, perhaps resulting in mislocalization due to the presence of an epitope tag or overexpression [ 20 21 22 24 25 ] . Second, by definition, those cells were largely cycling and thus were not representative of normal hematopoietic cells.
This strategy was based on the ability to functionally express GFP-nucleoporin fusions, and the assumption that NPC a ssembly/mislocalization mutants expressing a GFP-nucleoporin would have distinct fluorescence properties [ 26 ] . In wild type yeast cells, fluorescence microscopy localization of proteins at NPCs appears as punctate staining of virtually the entire nuclear rim circumference (see Figure 2).
The screen for NPC assembly/mislocalization mutants identified two genes that are part of the COPII coat, SEC13 and SEC23 . To test if other members of the COPII coat complex were isolated in the screen, conditional alleles in SEC16 , SEC24 , SEC31 , SAR1 , and SEC12 were kindly provided by other investigators, and tested directly for their effect on NPC localization.
The pattern of mislocalization in each case was similar to that observed in the isolated sec13 and sec23 mutants.
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