Example sentences for: microsomes

How can you use “microsomes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Firstly, Go and others [ 5 6 ] showed that mefloquine alters calcium flux into and out of isolated mammalian microsomes obtained from skeletal muscle and neuronal tissue.

  • The incorporation of fatty acids into the mitochondria and microsomes of colon, liver and tumor was determined in mice which consumed each diet.

  • It would be tempting to speculate that, because mefloquine's effects on rat neuronal ER calcium homeostasis were more potent than that for dog-brain microsomes, there might exist a species difference in sensitivity to the drug.

  • The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).

  • Total microsomes were washed twice with 0.6 M KCl buffer and 100 μg of total membrane protein was applied to a 5-15% SDS polyacrylamide gel.


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