Words similar to microsomes
Example sentences for: microsomes
How can you use “microsomes” in a sentence? Here are some example sentences to help you improve your vocabulary:
Firstly, Go and others [ 5 6 ] showed that mefloquine alters calcium flux into and out of isolated mammalian microsomes obtained from skeletal muscle and neuronal tissue.
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
Mefloquine has been found to alter calcium flux, into and out of, isolated skeletal muscle and brain microsomes, via an inhibitory effect of the compound on the ER calcium pump and calcium release channels (IC 50 of 42-43 uM, [ 27 28 ] ). Plasma mefloquine concentrations (therapeutic dosing) may reach 21 μM [ 18 ] and the drug crosses the blood-brain barrier, accumulating to concentrations in excess of 50 and 90 μM in the brains of humans and rats respectively [ 19 20 ] . Therefore, these biochemical effects occur at concentrations within a relevant physiological range.
Go and others [ 5 6 ] showed that mefloquine affects calcium flux into and out of isolated mammalian microsomes obtained from skeletal muscle and neuronal tissue.
It would be tempting to speculate that, because mefloquine's effects on rat neuronal ER calcium homeostasis were more potent than that for dog-brain microsomes, there might exist a species difference in sensitivity to the drug.
Loading...