Words similar to microsomes

Example sentences for: microsomes

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Li et al [ 5 ] also found that mefloquine inhibited calcium uptake into isolated microsomes from dog brain neurons - presumably via the same mechanism - although the drug was much less potent (IC 50 of 272 μM) than we are reporting it to be.
Go and others [ 5 6 ] showed that mefloquine affects calcium flux into and out of isolated mammalian microsomes obtained from skeletal muscle and neuronal tissue.
Total microsomes were washed twice with 0.6 M KCl buffer and 100 μg of total membrane protein was applied to a 5-15% SDS polyacrylamide gel.
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
also observed that mefloquine inhibited IP 3 -induced calcium release from isolated dog brain microsomes [ 5 ] . Our results do not preclude such a role for mefloquine in neuronal cells, although it would not have been possible to observe such an effect in the present study, since we investigated only the spontaneous action of mefloquine on ER calcium homeostasis.