Words similar to microsatellite
Example sentences for: microsatellite
How can you use “microsatellite” in a sentence? Here are some example sentences to help you improve your vocabulary:
Approximately 90% of the mouse genome is currently less than 2 cM from a typed microsatellite marker in the RI set.
M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .
Efforts to further localize the gene in this region will require the identification and typing of additional microsatellite markers and single nucleotide polymorphisms (SNPs) in a large cohort of SLE cases and controls.
More than 130 STSs were chosen from those in known genes, ESTs, polymorphic microsatellite markers, random genomic sequences, and BAC end sequences present in databases.
Mutations in microsatellite loci may be responsible for some heterozygosity [ 22].
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