Words similar to microdomains
Example sentences for: microdomains
How can you use “microdomains” in a sentence? Here are some example sentences to help you improve your vocabulary:
The membrane microdomains shown in Fig.
In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .
Indeed, we report here that the palmitoylated cysteine-string is responsible for the targeting of Rlk to RAFTs: detergent-insoluble, glycolipid-enriched membrane microdomains that contain many signaling molecules, including Src family kinases.
Specific CD98-integrin interaction occurs in the context of low density protein-lipid microdomains, possibly resembling lipid rafts [ 34 35 ] . Several important signaling molecules, including activated TCR, LAT and LCK are present in organized raft-type microdomains, and integrity of these microdomains is necessary for T cell receptor signal transduction [ 36 37 ] . Our present discovery that β1 integrins specifically associate with CD98 in lipid microdomains helps to explain the functional connections between β1 integrins and CD98 during T cell costimulation, monocyte fusion, and elsewhere.
Data suggest that, for Itk, this membrane association specifically targets the protein to glycolipid enriched detergent-insoluble membrane microdomains known as "RAFTs" and that both this association and the activation of Itk requires the PH domain [ 29].
Loading...