Words similar to microdomains
Example sentences for: microdomains
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In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .
In yeast, profilin null mutations result in cells that are viable at permissive temperature, but grow more slowly, are larger than wild type, and are often multinucleate [ 38 ] . The chickadee ( chic ) gene encodes Drosophila profilin and chic mutations produce sterile female flies [ 39 40 ] . In both species, profilin mutations resulted in defects in actin polymerization [ 38 39 40 ] . In addition to regulating actin assembly, a large body of in vitro and in vivo evidence suggests a role for profilin in signal transduction, mainly involving PIP2, a major second messenger that strongly binds to profilin [ 41 ] and localizes to the membrane microdomains described earlier.
Indeed, we report here that the palmitoylated cysteine-string is responsible for the targeting of Rlk to RAFTs: detergent-insoluble, glycolipid-enriched membrane microdomains that contain many signaling molecules, including Src family kinases.
One may speculate that the use of 0.05% Triton X-100 may have allowed maintenance of CD98 microdomains, needed for β1 interaction.
It is possible that short F-actin polymers, anchored at the microdomains, trigger syncytium.
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