Words similar to microbicide
Example sentences for: microbicide
How can you use “microbicide” in a sentence? Here are some example sentences to help you improve your vocabulary:
For this reason it was of interest to study the virucidal activity of anionic polymeric microbicide candidates against both X4 (using CXCR4 as coreceptor) and R5 (using CCR5 as coreceptor) viruses, the latter being most frequently transmitted sexually [ 39 ] .
Cellulose acetate phthalate (CAP) is a promising microbicide candidate for prevention of infection by sexually transmitted disease (STD) pathogens, including HIV-1 [ 1 2 3 4 5 6 7 ] . CAP inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120, while leaving the site for the primary cellular receptor CD4 accessible [ 8 9 ] Soluble CD4 (sCD4) was shown to inhibit HIV-1 infection by two mechanisms: reversible blockage of virus binding to receptors, and irreversible inactivation of virus infectivity [ 10 ] . Since CAP and sCD4 bind to distinct domains on the HIV-1 envelope, it was of interest to determine whether or not these two ligands affect virus infectivity synergistically as do other combinations of anti-HIV-1 drugs and sCD4 [ 11 12 ] Binding of sCD4 leads to conformational changes in gp120 [ 13 14 15 16 17 ] . Binding of gp120 to coreceptors CXCR4 and CCR5, respectively, triggers additional conformational changes in HIV-1 envelope glycoproteins [ 18 19 ] For these reasons it was of interest to determine whether a) pretreatment of HIV-1 with sCD4 would affect subsequent binding of CAP to virus particles, and b) CAP binding to virus particles in the presence or absence of sCD4 would elicit conformational changes which could affect HIV-1 infectivity.
To the best of our knowledge, results reported here and earlier [ 8 ] represent the most detailed study on the mechanism of action of a polymeric anti-HIV-1 compound and offer new opportunities for microbicide research, including the design of combined microbicides with distinct target sites on HIV-1 and acting synergistically.
virus inactivation rather than reversible inhibition) suggest that CAP is an ideal candidate compound for a vaginal microbicide expected to prevent sexual transmission of HIV-1.
3), it was of interest to determine whether any of the other anionic polymeric microbicide candidates affect the integrity of virus particles.
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