Example sentences for: methotrexate

How can you use “methotrexate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • methotrexate) are available to treat RA but are limited by significant toxicity requiring adjunct therapy, or are of variable efficacy.

  • Rheumatoid arthritis (RA) is a significant, chronic disease that afflicts 1% of the general population in most countries [ 1 ] . Joint damage typically occurs before patients are diagnosed, and most of the joint destruction occurs within the first 2 years of diagnosis [ 2 ] . Therapeutic drugs such as sulfasalazine and methotrexate (MTX) only slow the progression of the disease, suggesting that these drugs fail to adequately quell the underlying pathophysiology of RA [ 3 ] .

  • Currently the symptoms of arthritis are managed using pharmacologic agents, including both steroidal and nonsteroidal drugs, and disease-modifying drugs such as methotrexate.

  • Consistent with these pre-clinical studies, the design of this phase II trial involved a fluorouracil infusion that was initiated one hour into the 2 hour high dose infusion of LV and 36 hours after the initial methotrexate dosing.

  • 7% of patients; and chemotherapy (six cycles of cyclophosphamide, methotrexate, 5-fluorouracil [CMF] or four cycles of fluorouracil, epirubicin, cyclophosphamide [FEC]) in 33.


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