Words similar to metazocine
Example sentences for: metazocine
How can you use “metazocine” in a sentence? Here are some example sentences to help you improve your vocabulary:
Finally the four weakest agonists, cyclazocine, dezocine, metazocine and xorphanol all exhibited efficacies that showed statistically significant difference when compared to fentanyl (p < 0.01), and thus were categorized as partial agonists.
Thus the present study was designed, (1) to describe the activation profiles of a set of opioid ligands not previously defined at an isolated cell system expressing only δ opioid receptors, and (2) to compare the relative efficacies and potencies of these ligands to the strongest ligand in the set, metazocine, to the common opioid analgesic, morphine and to the endogenous δ opioid ligand, met-enkephalin.
Louis, MO), nalbuphine and met-enkephalin were obtained from RBI (Natik, MA), cyclazocine, etorphine, metazocine, morphine, nalorphine, and SKF 10047 were obtained from National Institute of Drug Abuse (Bethesda, MD), lofentanil was obtained from Janssen Pharmaceutical Inc. (Titusville, NJ), Dezocine was obtained from Wyeth Laboratories (Philadelphia, PA), Win 444,441 was obtained from Sterling Winthrop Pharmaceutical and Xorphanol was obtained from Miles Inc.
The rank order of potency of these ligands was; etorphine>lofentanil≥cyclazocine=xorphanol>met-enkephalin> Win 44,441=hydromorphone≥butorphanol>metazocine=SKF 10047> dezocine≥ nalbuphine>morphine>fentanyl.
The maximum effect of BW373U86 has been reported to be 70 ± 9% with IC 50 of 0.9 nM [ 21 ] . Some ligands that exhibited very low potencies in this study, such as fentanyl or metazocine, were amongst the most efficacious ligands tested suggesting that these ligands are capable of maximally activating δ opioid receptors.
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