Words similar to metal-coordinating
Example sentences for: metal-coordinating
How can you use “metal-coordinating” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
This version of the DPBB domain lacks the metal-coordinating motif but contributes two lysine residues, which are critical for substrate interactions in the catalytic cleft.
Thus, it appears likely that the ancestral DDRP evolved from the coalescence of at least 3 distinct domains: i) the DPBB that probably originally bound RNA and, subsequently, segregated into the cores of the β' subunit, where it acquired the metal-coordinating active site, and of the β subunit, with the two lysines projecting into the catalytic cleft (Fig.
The ability of a MIDAS protein to bind its protein ligand is tightly linked with the presence of intact MIDAS motifs: mutations to the metal-coordinating residues in these motifs, weaken or eliminate ligand binding [ 35 36 ] . An additional set of MIDAS-like proteins, that includes the integrin β-chain [ 37 38 ] and the von Willebrand Factor A domain [ 27 ] , lacks one of the three motifs and appears to bind ligands in a somewhat different manner [ 27 39 40 ] . In midasin, the presence of all three MIDAS motifs in the M-domain, with the putative metal ion-binding residues in the motifs invariant in the available organisms, indicates that midasin belongs to the family of MIDAS-containing proteins.
Taken together, these observations suggest that, although RDRPs and the β' subunits of DDRPs show limited sequence similarity, these two RNA polymerase families share a homologous catalytic domain, which consists of a double-psi-β-barrel containing the metal-coordinating DbDGD motif.
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