Words similar to metal-coordinating
Example sentences for: metal-coordinating
How can you use “metal-coordinating” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ability of a MIDAS protein to bind its protein ligand is tightly linked with the presence of intact MIDAS motifs: mutations to the metal-coordinating residues in these motifs, weaken or eliminate ligand binding [ 35 36 ] . An additional set of MIDAS-like proteins, that includes the integrin β-chain [ 37 38 ] and the von Willebrand Factor A domain [ 27 ] , lacks one of the three motifs and appears to bind ligands in a somewhat different manner [ 27 39 40 ] . In midasin, the presence of all three MIDAS motifs in the M-domain, with the putative metal ion-binding residues in the motifs invariant in the available organisms, indicates that midasin belongs to the family of MIDAS-containing proteins.
Taken together, these observations suggest that, although RDRPs and the β' subunits of DDRPs show limited sequence similarity, these two RNA polymerase families share a homologous catalytic domain, which consists of a double-psi-β-barrel containing the metal-coordinating DbDGD motif.
Thus, it appears likely that the ancestral DDRP evolved from the coalescence of at least 3 distinct domains: i) the DPBB that probably originally bound RNA and, subsequently, segregated into the cores of the β' subunit, where it acquired the metal-coordinating active site, and of the β subunit, with the two lysines projecting into the catalytic cleft (Fig.
One of these corresponds to the catalytic, metal-coordinating domain, containing the DbDGD motif, in the β' subunit (residues: 626-750 of pdb id:1iw7 chain D), whereas the other one corresponds to the conserved core domain of the β subunit (residues:673-994 of pdb id: 1iw7 chain C).
We also present evidence that RDRP and the ubiquitous β' subunit of DDRP contain a homologous, metal-coordinating, catalytic domain.
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