Words similar to metal-binding
Example sentences for: metal-binding
How can you use “metal-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The characteristic motifs of metallo-β-lactamases, which mostly include metal-binding histidines, are highly conserved in MJ0301 and its orthologs (Figure 3).
However, despite extensive comparisons using PSSM and careful visual examination, we failed to detect any residual sequence similarity between DDRP and RDRP, outside the core DPBB domain containing the metal-binding active site.
Analogous to the RecT superfamily, this acidic dyad might coordinate a divalent cation and undergo a conformational change dependent on metal-binding.
The residues in the MIDAS motifs lie on three closely apposed loops located on the upper edge of the β-sheet, where they form the metal-binding site, with oxygen atoms in the aspartate, serine and threonine residues coordinating the metal ion [ 9 ] . In integrin α2β1, which is a collagen receptor, the metal-binding site also binds the collagen ligand through the conserved glutamate in a GFOGER motif (O = hydroxyproline) completing the coordination sphere of the metal [ 28 ] . In vivo, the binding of collagen at this site appears to be regulated through a conformational shift in which the loops forming the MIDAS site change from a closed to an open conformation [ 29 30 31 ] . Other proteins containing a domain with all three MIDAS motifs include the D-subunit of magnesium chelatase [ 32 ] , Ca-activated chloride-channel protein [ 33 34 ] , nitrate reductase (accession AAC79447), and the D subunit of nitric oxide reductase (accession AAC45374).
These suggestive features include the fusion with a ferredoxin domain seen in the M. thermoautotrophicum member MTH601, the insertion of the metal-binding module in certain members, including MJ0757 (see above), and the presence of three cysteines that are conserved throughout this family.
Loading...