Words similar to mesangial
Example sentences for: mesangial
How can you use “mesangial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Early abnormalities of DNP affect glomeruli and include an increase in glomerular filtration rate, microalbuminuria, glomerular hypertrophy, and thickening of the glomerular basement membrane, followed by expansion of mesangial extracellular matrix and glomerulosclerosis [1,2].
Using microarray-based gene expression profiling on whole kidney RNA together with supervised clustering methods, we previously identified and validated gene expression patterns for molecular classification of diabetic mice with albuminuria and mesangial expansion [5].
The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
In the absence of SPARC, expression of transforming growth factor-β1 and type I collagen is down-regulated in kidney mesangial cells [ 15 ] . The expression of cell surface receptor for insulin-like growth factor I in SPARC-null embryonic fibroblasts is also diminished [ 16 ] . Studies with SPARC-null cells have confirmed that SPARC functions in cell proliferation.
Mesangial cells, adult skin fibroblasts and smooth muscle cells from SPARC-null mice proliferate faster than their respective wild-type counterparts in media containing fetal bovine serum (FBS) [ 17 ] . Although embryonic fibroblasts from the SPARC-null mice grow at the same rate as the wild-type cells when they are cultured in FBS, the SPARC-null embryonic fibroblasts exhibit down-regulated proliferation as compared to the wild-type cells when the fibroblasts are cultured in serum-free medium containing insulin as the sole mitogenic factor [ 16 ] . Thus, it appears that the role of SPARC in cell proliferation is cell type and environment dependent.
Loading...