Words similar to mesangial
Example sentences for: mesangial
How can you use “mesangial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Early abnormalities of DNP affect glomeruli and include an increase in glomerular filtration rate, microalbuminuria, glomerular hypertrophy, and thickening of the glomerular basement membrane, followed by expansion of mesangial extracellular matrix and glomerulosclerosis [1,2].
The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
Periodic acid–Schiff–stained sections of kidneys from mice exposed to type 2 diabetes (db/db mice) for 20 wk (Figure 2A), or type 1 diabetes (STZ-treated C57BL/6J mice) for 20 wk (data not shown) demonstrated moderate to advanced mesangial expansion and glomerulosclerosis (Figure 2A).
In contrast, in diabetic mice with albuminuria, mesangial expansion, and glomerulosclerosis, absence of CD36 expression was associated with normal appearance of the tubular epithelium and interstitial space.
Using microarray-based gene expression profiling on whole kidney RNA together with supervised clustering methods, we previously identified and validated gene expression patterns for molecular classification of diabetic mice with albuminuria and mesangial expansion [5].
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