Words similar to mesangial
Example sentences for: mesangial
How can you use “mesangial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Using microarray-based gene expression profiling on whole kidney RNA together with supervised clustering methods, we previously identified and validated gene expression patterns for molecular classification of diabetic mice with albuminuria and mesangial expansion [5].
In the absence of SPARC, expression of transforming growth factor-β1 and type I collagen is down-regulated in kidney mesangial cells [ 15 ] . The expression of cell surface receptor for insulin-like growth factor I in SPARC-null embryonic fibroblasts is also diminished [ 16 ] . Studies with SPARC-null cells have confirmed that SPARC functions in cell proliferation.
In contrast, TED and IF were associated with moderate to advanced mesangial expansion and glomerulosclerosis on kidney sections of human DNP (Figure 2B).
Periodic acid–Schiff–stained sections of kidneys from mice exposed to type 2 diabetes (db/db mice) for 20 wk (Figure 2A), or type 1 diabetes (STZ-treated C57BL/6J mice) for 20 wk (data not shown) demonstrated moderate to advanced mesangial expansion and glomerulosclerosis (Figure 2A).
Mesangial cells, adult skin fibroblasts and smooth muscle cells from SPARC-null mice proliferate faster than their respective wild-type counterparts in media containing fetal bovine serum (FBS) [ 17 ] . Although embryonic fibroblasts from the SPARC-null mice grow at the same rate as the wild-type cells when they are cultured in FBS, the SPARC-null embryonic fibroblasts exhibit down-regulated proliferation as compared to the wild-type cells when the fibroblasts are cultured in serum-free medium containing insulin as the sole mitogenic factor [ 16 ] . Thus, it appears that the role of SPARC in cell proliferation is cell type and environment dependent.
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