Words similar to melanomas
Example sentences for: melanomas
How can you use “melanomas” in a sentence? Here are some example sentences to help you improve your vocabulary:
Morphology appears to be the single most important tool facilitating their correct interpretation [ 6 ] . Other approaches, including the observation that capsular nevi are non-immunoreactive or weakly immunoreactive for HMB45, have been suggested for differentiating capsular nevi from melanoma micrometastases [ 21 ] . However, it is important to note that a significant number of melanomas are also non-immunoreactive for HMB45.
Rare SPAM1 transcripts are however not ubiquitous as revealed by their absence from human ovary, spleen, and liver [ 21 ] and murine skeletal muscle [ 22 ] . Both rare and abundant SPAM1 transcripts have been found in neoplastic breast tissue [ 23 ] and in a number of other cancers including pharyngeal [ 24 ] , metastatic melanomas and gliomas [ 25 ] . In normal somatic cells rare transcripts have been found in breast tissue [ 23 ] and in fetal, placental, and prostate cDNA libraries [ 21 ] .
Clinically, TYRP-1 is thought to be important as a melanoma antigen that is highly antigenic to cytotoxic T cells, providing a potential target for melanoma vaccine development [ 16 ] . TYRP-1 appears to be less expressed in advanced primary lesions and metastases of human cutaneous melanoma and uveal melanoma [ 32 ] . Primary melanoma samples express TYRP-1 transcripts at higher levels than melanoma metastases [ 33 ] , and IHC analysis of malignant melanocytic lesions has shown that the invasive cells of primary melanomas are TYRP-1-negative [ 34 ] .
As a standardization process to confirm positive immunoreactivity, 35 melanomas (including one spindle cell melanoma and one clear cell melanoma) were evaluated.
One such member of this receptor family is the avß3 integrin, which is expressed on both the tumor cells and the new vasculature of various tumors, including melanomas.
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