Example sentences for: melanocytic

How can you use “melanocytic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our finding that TYRP-1 is also expressed in the poorly metastatic or noninvasive cell lines NM-2C5 [ 2 ] , T47D, MCF7 and DU145 [ 5 ] , which are derived from human breast cancers and prostate tumors that are nonmetastatic, indicates that this molecule is not exclusively expressed in cells of the melanocytic lineage.

  • Although, these melanocytic capsular nevi appear benign morphologically, a low probability that they may represent subtle metastases was also considered.

  • As compared to this, none of the 81 slices of sentinel lymph nodes from 30 cases of mammary carcinoma showed capsular melanocytic nevi.

  • Hypothetically, an association between the higher prevalence of melanocytic capsular nevi and the predisposition for melanoma may be likely.

  • Clinically, TYRP-1 is thought to be important as a melanoma antigen that is highly antigenic to cytotoxic T cells, providing a potential target for melanoma vaccine development [ 16 ] . TYRP-1 appears to be less expressed in advanced primary lesions and metastases of human cutaneous melanoma and uveal melanoma [ 32 ] . Primary melanoma samples express TYRP-1 transcripts at higher levels than melanoma metastases [ 33 ] , and IHC analysis of malignant melanocytic lesions has shown that the invasive cells of primary melanomas are TYRP-1-negative [ 34 ] .


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