Words similar to melanocortin

Example sentences for: melanocortin

How can you use “melanocortin” in a sentence? Here are some example sentences to help you improve your vocabulary:

POMC is cleaved post-translationally producing bioactive peptides (adrenocorticotrophin, β-endorphin and α-, β- and γ-melanocyte stimulating hormones) that interact with neurons expressing melanocortin receptors, leading to appetite suppression [ 91 ] . Feeding high fat diets is known to increase Pomc expression [ 92 ] . Herein, FUNG feeding resulted in a 6.0* fold increase in hippocampal Pomc, whereas FISH and the combination diet had smaller, non-statistically significant effects (6.
Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.
However, factors that regulate hypothalamic melanocortin tone are not fully elucidated.
These data raise the possibility that potential anti-obesity drugs based on reducing glucocorticoid tone or elevating melanocortin tone may have limited efficacy in treating forms of obesity in which those systems are not perturbed.
Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.