Words similar to melanocortin

Example sentences for: melanocortin

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3A), and serum insulin, leptin and melanocortin tone were also reduced in this condition (Fig.
Since both fasting and insulin deficiency are associated with reduced plasma leptin [ 5 ] , and leptin replacement reverses effects of fasting [ 6 ] and also effects of insulin deficiency on food intake and body weight [ 7 ] , it has been suggested that the reduction in leptin accounts for the reduced hypothalamic melanocortin tone in these conditions.
Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
However, factors that regulate hypothalamic melanocortin tone are not fully elucidated.