Words similar to melanocortin

Example sentences for: melanocortin

How can you use “melanocortin” in a sentence? Here are some example sentences to help you improve your vocabulary:

Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.
POMC is cleaved post-translationally producing bioactive peptides (adrenocorticotrophin, β-endorphin and α-, β- and γ-melanocyte stimulating hormones) that interact with neurons expressing melanocortin receptors, leading to appetite suppression [ 91 ] . Feeding high fat diets is known to increase Pomc expression [ 92 ] . Herein, FUNG feeding resulted in a 6.0* fold increase in hippocampal Pomc, whereas FISH and the combination diet had smaller, non-statistically significant effects (6.
[ 14 ] . These data suggest that leptin's effect to reverse effects of fasting on melanocortin tone may require and be mediated by a reduction in glucocorticoids.
Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.
Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.