Words similar to melanocortin

Example sentences for: melanocortin

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1Band 1C) as well as melanocortin tone (Fig.
Since both fasting and insulin deficiency are associated with reduced plasma leptin [ 5 ] , and leptin replacement reverses effects of fasting [ 6 ] and also effects of insulin deficiency on food intake and body weight [ 7 ] , it has been suggested that the reduction in leptin accounts for the reduced hypothalamic melanocortin tone in these conditions.
Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.
[ 14 ] . These data suggest that leptin's effect to reverse effects of fasting on melanocortin tone may require and be mediated by a reduction in glucocorticoids.
Although a reduction in plasma leptin plays an important role in mediating neuroendocrine responses to fasting [ 6 ] and diabetes [ 17 ] , we have previously demonstrated that fasting can regulate hypothalamic melanocortin tone independently of both leptin and insulin [ 5 ] . The present studies suggest that corticosterone may play a role in mediating these leptin-independent effects.