Words similar to melanocortin
Example sentences for: melanocortin
How can you use “melanocortin” in a sentence? Here are some example sentences to help you improve your vocabulary:
POMC is cleaved post-translationally producing bioactive peptides (adrenocorticotrophin, β-endorphin and α-, β- and γ-melanocyte stimulating hormones) that interact with neurons expressing melanocortin receptors, leading to appetite suppression [ 91 ] . Feeding high fat diets is known to increase Pomc expression [ 92 ] . Herein, FUNG feeding resulted in a 6.0* fold increase in hippocampal Pomc, whereas FISH and the combination diet had smaller, non-statistically significant effects (6.
concerning NPY [ 14 ] , and suggesting that increases in corticosterone mediate fasting-induced changes in melanocortin tone.
After more chronic exposure, this delicate balance could plausibly become disrupted, leading to glucocorticoid-mediated development of the metabolic syndrome [ 10 ] . Thus interactions between insulin, leptin, and glucocorticoids, and the neuropeptide responses they generate within the melanocortin system, allow complex metabolic responses to nutritional status but may also allow the development of metabolic pathologies.
Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.
Although a reduction in plasma leptin plays an important role in mediating neuroendocrine responses to fasting [ 6 ] and diabetes [ 17 ] , we have previously demonstrated that fasting can regulate hypothalamic melanocortin tone independently of both leptin and insulin [ 5 ] . The present studies suggest that corticosterone may play a role in mediating these leptin-independent effects.
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