Words similar to melanocortin

Example sentences for: melanocortin

How can you use “melanocortin” in a sentence? Here are some example sentences to help you improve your vocabulary:

Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.
We had previously shown that fasting could regulate hypothalamic gene expression in insulin-deficient mice even though in these mice fasting did not influence plasma leptin or insulin [ 5 ] . Since adrenalectomy blocked the fasting-induced reduction in melanocortin tone in diabetic mice (as it had in euglycemic mice in the first study), these results suggest that effects of fasting on melanocortin tone in diabetic mice may be mediated at least in part by a rise in plasma corticosterone (itself possibly secondary to the reduction in plasma leptin).
However, factors that regulate hypothalamic melanocortin tone are not fully elucidated.
Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.
Since both fasting and insulin deficiency are associated with reduced plasma leptin [ 5 ] , and leptin replacement reverses effects of fasting [ 6 ] and also effects of insulin deficiency on food intake and body weight [ 7 ] , it has been suggested that the reduction in leptin accounts for the reduced hypothalamic melanocortin tone in these conditions.