Words similar to melanocortin
Example sentences for: melanocortin
How can you use “melanocortin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
These data raise the possibility that potential anti-obesity drugs based on reducing glucocorticoid tone or elevating melanocortin tone may have limited efficacy in treating forms of obesity in which those systems are not perturbed.
Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.
[ 14 ] . These data suggest that leptin's effect to reverse effects of fasting on melanocortin tone may require and be mediated by a reduction in glucocorticoids.
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