Words similar to mefloquine

Example sentences for: mefloquine

How can you use “mefloquine” in a sentence? Here are some example sentences to help you improve your vocabulary:

[ 3 ] In the late 1980s it became clear that mefloquine could cause neuropsychiatric adverse effects.
In this study, an attempt was made to deduce a possible mechanism of action for mefloquine in rat neuronal cells using Affymetrix rat toxicology arrays.
We retrieved and critically reviewed all the original papers listed in the Cochrane review to clarify the phenomenology of the adverse effects associated with mefloquine, and to look for clues to possibly safer use of the drug.
Thapsigargin antagonizes the disruptive effect of mefloquine on calcium homeostasis and protects neurons from cellular injury
Mefloquine has been found to alter calcium flux, into and out of, isolated skeletal muscle and brain microsomes, via an inhibitory effect of the compound on the ER calcium pump and calcium release channels (IC 50 of 42-43 uM, [ 27 28 ] ). Plasma mefloquine concentrations (therapeutic dosing) may reach 21 μM [ 18 ] and the drug crosses the blood-brain barrier, accumulating to concentrations in excess of 50 and 90 μM in the brains of humans and rats respectively [ 19 20 ] . Therefore, these biochemical effects occur at concentrations within a relevant physiological range.