Example sentences for: mefloquine

How can you use “mefloquine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Firstly, shorter toxicant exposure time ensured that any changes observed in specific mRNA transcript levels were due to the direct cellular effects of mefloquine, rather than secondary effects caused by changing culture conditions (since drug-treated NG108 cells divide less rapidly than DMSO-treated cells).

  • Mefloquine use has been associated with two broad classes of neurological disorders: (i) central and peripheral nervous system disorders including headache, dizziness, vertigo and seizures and (ii) psychiatric events including insomnia, anxiety, affective and major disorders [ 2 ] . It is well known and has been accepted for some time that prolonged disruptions in Ca 2+homeostasis can result in impairment of neuronal function and cell death [ 18 19 ] . Impairment or loss of neurons in specific regions of the brain might be manifested in symptoms reported to have occurred in patients treated with mefloquine.

  • After treatment, mefloquine dilutions were removed and replaced with MEM (Gibco).

  • Mefloquine upregulates the transcription of important ER stress response genes

  • Pre-treatment with thapsigargin (4 μM) antagonised both the initial rise in intracellular calcium attributable to the effect of mefloquine on the ER calcium store, and the subsequent sustained influx of external calcium (Figure 4).


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