Words similar to medulloblastomas
Example sentences for: medulloblastomas
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Literature profiles were generated for a second large dataset consisting of the 200 genes and ESTs found to be the most differentially regulated in classic versus desmoplastic medulloblastomas in a study of central nervous system tumors [ 19].
We have previously shown that nuclear β-catenin is present in 18% of sporadic medulloblastomas [ 18 ] .
APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.
In order to determine if Wnt signaling was aberrantly active in the cerebellar neuroblasts thought to give rise to some medulloblastomas, β-catenin immunostains were performed on newborn Mut-1 and Mut-2 animals.
The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
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