Words similar to medulloblastomas
Example sentences for: medulloblastomas
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APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.
In order to determine if Wnt signaling was aberrantly active in the cerebellar neuroblasts thought to give rise to some medulloblastomas, β-catenin immunostains were performed on newborn Mut-1 and Mut-2 animals.
Strain effects are unlikely to have played a role in this lack of a neoplastic phenotype, as mice with the same background as the one we used have previously been shown to develop medulloblastomas [ 12 ] . We further attempted to induce CNS tumors by abrogating p53 function in conjunction with transgenic β-catenin expression.
Literature profiles were generated for a second large dataset consisting of the 200 genes and ESTs found to be the most differentially regulated in classic versus desmoplastic medulloblastomas in a study of central nervous system tumors [ 19].
In man, three inherited syndromes associated with medulloblastomas have been described: Turcot's, Gorlin's and Li Fraumeni (reviewed in [ 1 ] ). Li Fraumeni syndrome is caused by inherited mutations in the p53 tumor suppressor gene.
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