Words similar to medulloblastomas
Example sentences for: medulloblastomas
How can you use “medulloblastomas” in a sentence? Here are some example sentences to help you improve your vocabulary:
In man, three inherited syndromes associated with medulloblastomas have been described: Turcot's, Gorlin's and Li Fraumeni (reviewed in [ 1 ] ). Li Fraumeni syndrome is caused by inherited mutations in the p53 tumor suppressor gene.
In order to determine if Wnt signaling was aberrantly active in the cerebellar neuroblasts thought to give rise to some medulloblastomas, β-catenin immunostains were performed on newborn Mut-1 and Mut-2 animals.
Mice heterozygous for PTCH and lacking p53 all developed medulloblastomas by 3 months of age [ 12 ] .
The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.
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