Words similar to medulloblastomas

Example sentences for: medulloblastomas

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Strain effects are unlikely to have played a role in this lack of a neoplastic phenotype, as mice with the same background as the one we used have previously been shown to develop medulloblastomas [ 12 ] . We further attempted to induce CNS tumors by abrogating p53 function in conjunction with transgenic β-catenin expression.
In order to determine if Wnt signaling was aberrantly active in the cerebellar neuroblasts thought to give rise to some medulloblastomas, β-catenin immunostains were performed on newborn Mut-1 and Mut-2 animals.
The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
Literature profiles were generated for a second large dataset consisting of the 200 genes and ESTs found to be the most differentially regulated in classic versus desmoplastic medulloblastomas in a study of central nervous system tumors [ 19].
Affected individuals develop a large spectrum of CNS and extra-CNS neoplasms, including medulloblastomas [ 2 ] . Interestingly, alterations in p53 are relatively rare in sporadic medulloblastomas, with mutations detected in 5% or less of cases [ 3 4 ] .