Example sentences for: medulloblastoma

How can you use “medulloblastoma” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.

  • Mutations in the Hedgehog pathway members PTCH , PTCH 2 , SUFU and Smo , have all been identified in sporadic medulloblastomas as well, with approximately 25% of cases containing mutations affecting these genes [ 5 6 7 8 9 ] . A murine medulloblastoma model was recently developed by disruption of the PTCH gene, with medulloblastoma-like tumors arising in 10-15% of heterozygotes by 9 months of age [ 10 11 ] . Breeding PTCH mice to p53 knockout animals markedly increased tumor incidence.

  • Overall, our data suggest that activation of Wnt signaling in adult cerebellar and cortical neurons may not be sufficient for formation of medulloblastoma/PNET.

  • First, co-transfection of the cDNA used to make our transgenic mice and the TOPFLASH Wnt pathway reporter plasmid into DAOY medulloblastoma cells resulted in over forty-fold induction of reporter activity.

  • Transcriptional activity of β-catenin constructs in medulloblastoma DAOY cells


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