Words similar to mechanistically
Example sentences for: mechanistically
How can you use “mechanistically” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mechanistically, HIV-1 Tat elicited a general suppression of gene expression, including that of Xbra and gsc , two early genes whose expression are required for proper gastrulation [ 17 ] .
The M6P/IGF2R is also mechanistically involved in the genesis of human cancer [ 6 20 21 22 23 24 ] . M6P/IGF2R loss of heterozygosity coupled with intragenic loss-of-function mutations in the remaining allele is a common event in human cancers [ 6 20 21 22 ] . Inheritance of a tandem repeat polymorphism in the 3' UTR of M6P/IGF2R furthermore predicts for enhanced susceptibility to oral cancer [ 25 ] . Moreover, tumor cell growth is inhibited when M6P/IGF2R expression is restored to normal while it is increased when gene expression is reduced [ 26 27 28 29 ] . The results of these mutational and functional studies clearly demonstrate that the M6P/IGF2R possesses the characteristics necessary to be classified as a tumor suppressor gene [ 30 ] .
The uORFs are involved mechanistically in bringing about enhanced translation initiation under conditions that otherwise favor a general decrease in translation initiation [ 25 ] . Within the 5' UTR of countin mRNA, we find uORFs similar in number and in arrangement to those of GCN4 mRNA, the major mRNA regulated by yeast GCN2 [ 25 ] . Thus, we suggest that countin mRNA, and probably other as yet identified mRNAs, are translationally upregulated when IfkA phosphorylates eIF2α during the preaggregation period, or from 1 to 7 hours after the onset of development.
The different effects of the isolated DBD on G1 and S blockage indicated that C/EBPα regulation of G1 and S phase arrest was mechanistically distinct.
Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.
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