Example sentences for: mechanistically

How can you use “mechanistically” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The phylogenetic relationship we demonstrate between the LRAT family of enzymes and thiol peptidases shows that this catalytic triad was derived only once in evolution and re-used for different mechanistically similar reactions such as acyl transfer, transacylation or peptide-bond hydrolysis.

  • The uORFs are involved mechanistically in the enhanced initiation of these mRNAs [ 25 ] .

  • The effects of human papilloma virus E7 proteins on C/EBPα-induced differentiation and growth arrest also suggest that the effects of C/EBPα on proliferation are mechanistically divergent [ 40 ] . Having distinct mechanisms for regulation of gene transcription and proliferation allows a transcription factor to regulate these two critical processes completely independently of one another.

  • The different effects of the isolated DBD on G1 and S blockage indicated that C/EBPα regulation of G1 and S phase arrest was mechanistically distinct.

  • The M6P/IGF2R is also mechanistically involved in the genesis of human cancer [ 6 20 21 22 23 24 ] . M6P/IGF2R loss of heterozygosity coupled with intragenic loss-of-function mutations in the remaining allele is a common event in human cancers [ 6 20 21 22 ] . Inheritance of a tandem repeat polymorphism in the 3' UTR of M6P/IGF2R furthermore predicts for enhanced susceptibility to oral cancer [ 25 ] . Moreover, tumor cell growth is inhibited when M6P/IGF2R expression is restored to normal while it is increased when gene expression is reduced [ 26 27 28 29 ] . The results of these mutational and functional studies clearly demonstrate that the M6P/IGF2R possesses the characteristics necessary to be classified as a tumor suppressor gene [ 30 ] .


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