Example sentences for: mcp-
How can you use “mcp-” in a sentence? Here are some example sentences to help you improve your vocabulary:
MCP-1 and IL-8 play a role in migration of monocytes
The fibroblast line expressed mRNAs for IL-8, MCP-1, and IP-10, but not RANTES, MIP-1α, and MIP-1β.
The current study indicates a wider profile of chemokine expression and secretion by RA SCL, and also a greater production of IL-8 and MCP-1 by RA SCL compared with OA SCL, implying a greater proinflammatory potential.
The CXC chemokines such as IL-8 were originally identified as potent activators and chemoattractants for neutrophils, whereas the CC chemokines such as MCP-1 and RANTES mostly attract monocytes and eosinophils respectively [ 10 ] . Chemokines are secreted in a stimulus-and cell type-specific manner [ 11 12 13 14 15 16 17 ] and are regulated primarily at the level of gene transcription [ 18 19 20 21 22 23 24 ] . The transcriptional promoters of IL-8, RANTES and MCP-1 contain binding sites for the redox-responsive transcription factor NF-κB, which has been shown to be important for their regulation by viral infections and cytokines [ 18 20 23 25 26 27 28 29 30 31 32 33 34 ] .
ELISA = enzyme-linked immunosorbent assay; IP-10 = interferon-gamma inducible protein 10; mAb = monoclonal antibody; MCP-1 = monocytechemotactic protein-1; MIP = macrophage inflammatory protein; OA = osteoarthritis; PBMC = peripheral blood mononuclear cells; PE = phycoerythrin;RA = rheumatoid arthritis; RANTES = regulated upon activation, normal T cell expressed and secreted; RT-PCR = reverse transcriptase-polymerasechain reaction; SCL = stromal cell line; SRBC = sheep red blood cells; TNF-α = tumor necrosis factor-α.
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