Example sentences for: mcp-
How can you use “mcp-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inhibitor studies correlating chemokine gene expression and NF-κB binding activity indicate that RSV, in contrast to TNFα, induces IL-8, MCP-1 and RANTES expression in A549 epithelial cells through a redox-sensitive NF-κB signaling pathway that appears to involve predominately Rel A. IL-8, MCP-1 and RANTES are known redox regulated genes and our results are consistent with the findings that oxidant tone can regulate chemokine gene expression in RSV infected airway epithelial cells [ 46 47 48 ] .
MCP-1 has been shown to play an important role in the development of arthritis in MRL-lpr mice [ 22], whereas the migration of monocytes into inflammatory sites was reduced in the CCR2-deficient mouse [ 23].
Therefore, cytokines (TNF-α, IL-1β, and IL-6), a C-C type chemokine (MCP-1/CCL2), and a C-X-C type chemokine (MIP-2/CXCL2) are all up regulated at the RNA level by bacterial product interaction with the epithelial cells.
The data indicate that MCP-1 secreted by synovial stromal cells plays a major role in attracting monocytes to the synovium, and that IL-8 may also contribute.
The CXC chemokines such as IL-8 were originally identified as potent activators and chemoattractants for neutrophils, whereas the CC chemokines such as MCP-1 and RANTES mostly attract monocytes and eosinophils respectively [ 10 ] . Chemokines are secreted in a stimulus-and cell type-specific manner [ 11 12 13 14 15 16 17 ] and are regulated primarily at the level of gene transcription [ 18 19 20 21 22 23 24 ] . The transcriptional promoters of IL-8, RANTES and MCP-1 contain binding sites for the redox-responsive transcription factor NF-κB, which has been shown to be important for their regulation by viral infections and cytokines [ 18 20 23 25 26 27 28 29 30 31 32 33 34 ] .
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