Words similar to maximal
Example sentences for: maximal
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The data in Figure 3demonstrate that the effect of a one- and two-base mismatch is maximal using a hybridization time equal to or greater than sixteen hours.
Both fentanyl and hydromorphone showed maximal efficacies that were not significantly different compared to that of the endogenous ligand β-endorphin (P > 0.05), thus categorizing them as full agonists compared to β-endorphin.
There are two homologous type IA topoisomerases present in E. coli . Topoisomerase III has potent DNA decatenating activity for resolution of plasmid DNA replication intermediates, but much weaker relaxation activity than topoisomerase I [ 17 ] . To exhibit maximal relaxation activity, topoisomerase III requires high temperature (52°C) along with low magnesium and monovalent ion [ 17 18 ] . In contrast, E. coli topoisomerase I was not active in the in vitro assay for resolution of plasmid DNA replication intermediates [ 19 ] . Removal of the C-terminal 49 amino acids from the 653 amino acid topoisomerase III protein resulted in drastic reduction of catalytic activity [ 20 ] . Fusion of the carboxyl-terminal 312 amino acid residues of E. coli topoisomerase I, which includes the entire ZD domain, onto the 605 N-terminal amino acids of topoisomerase III generated a hybrid topoisomerase that has relaxation activity resembling topoisomerase III along with weak decatenating activity [ 21 ] . Although preferring single-stranded DNA as binding substrate, topoisomerase I had been shown to also bind double-stranded DNA [ 22 ] , but there is no data available to indicate which domain in the enzyme is responsible for this interaction.
Consistent with the mRNA data, the maximal inhibition of collagen promoter activity was 60% (Fig.
Maximal inhibitory effect of each ligand was compared to the levels of maximal inhibition by β-endorphin, fentanyl, morphine and xorphanol using ANOVA analysis with Dunnett's multiple comparison as post-test using PRISM software (GraphPad Software, Inc.
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