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Example sentences for: mart-
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8%–87%), and these responses were specific as they had little response to A375, a HLA-A*0201-positive melanoma cell that does not express gp100 or MART-1 and served as a negative control for antigen-specific killing (Table 1; 2.7% and 3%).
As previously reported, MART-1 and Melan-A demonstrated predominantly cytoplasmic staining of melanoma cells [ 6 ] . The monoclonal antibody (T311) to tyrosinase, has been reported to demonstrate high sensitivity and specificity for melanoma [ 13 ] . It has also demonstrated an immunostaining pattern in sentinel lymph nodes identical to MART-1 and Melan-A.
We also compared the cocktail against MART-1 and Melan-A individually.
As expected, combining a monoclonal antibody to tyrosinase with MART-1 and Melan-A in the cocktail increased the spectrum to encompass three epitopes of two melanoma antigens (MART-1/Melan-A and tyrosinase).
It is possible to use a combination of monoclonal antibodies to MART-1, Melan-A, and Tyrosinase as a single cocktail reagent on one glass slide in contrast to three individual antibodies on three slides.