Example sentences for: mapk

How can you use “mapk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This finding is supported by the observation that activation of p21/Ras and MAPK ERK1/2 induced by TGFβ 1 is only reverted to the control level by the combination of the TGFβ-RII blocking antibody and the α V β 6 -blocking antibodies, or by inhibition of MEK1.

  • Insulin does not activate p44/42 MAPK and does not inhibit SP-A gene transcription via the MAPK pathway.

  • Biochemical studies of Btk-deficient B cells have shown Btk to be necessary for BCR-induced phospholipase C-γ2 (PLCγ2) phosphorylation, calcium mobilization, extracellular signal-regulated kinase (ERK) and c-Jun NH 2 -terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation, NF-κB activation and apoptosis [ 7, 8, 9, 10, 11, 12].

  • In contrast, insulin signal transduction pathways are well-characterized in a wide variety of cell types [ 8 10 ] . Insulin is known to primarily transduce its cellular actions via two signaling pathways, the p44/42 MAPK pathway and the PI 3-kinase pathway [ 8 10 ] . In the present study, we investigated the signaling pathways that mediate the inhibitory effects of insulin on the expression of the SP-A genes in human lung epithelial cells.

  • In addition, insulin had no effect on p44/42 MAPK phosphorylation during a 2-hour incubation.


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