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Example sentences for: maoa
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The MAOA and MAOB genes are located on the X chromosome (Xp11) [ 63 ] and code for enzymes that catalyze the deamination of biogenic amines including the neurotransmitters norephinephrine, dopamine and serotonin.
Zygosity status was determined by close inspection of physical features, birth records, parental interview and genotyping of buccal swab DNA at 6 polymorphic genetic loci: maoa, drd3, dbh, maoa, b1adr and gsalpha [ 49 50 51 52 53 ] .
No significant main effect or trend was observed for either MAOA polymorphism and overall reaction time.
In order to assess the role of dopamine on executive attention network efficiency, it would be useful to compare the distributions of executive attention scores for these 2 polymorphisms and ask whether those individuals who are expected to have higher levels of dopamine (COMT Methionine and MAOA 3-repeat) show differences in executive attention when compared to those individuals with lower levels of dopamine.
Because of its metabolic role, drugs which interfere with MAOA such as clorgyline have been used to treat ADHD [ 64 ] . The most notable of MAOA polymorphism was a nonsense mutation that led to a complete loss of MAOA function in males showing extreme forms of impulsive behavior and aggression [ 65 ] . More recently, the association with aggression was replicated in a study showing that maltreated children with certain alleles of MAOA were more likely to show aggressive behaviors [ 66 ] . MAOA male knockout mice also show high levels of aggression [ 67 ] . Less severe genetic variants are known to exist in MAOA which have been studied as candidates to explain various dimensions of psychiatric illness.
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