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Example sentences for: maoa

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Because of its metabolic role, drugs which interfere with MAOA such as clorgyline have been used to treat ADHD [ 64 ] . The most notable of MAOA polymorphism was a nonsense mutation that led to a complete loss of MAOA function in males showing extreme forms of impulsive behavior and aggression [ 65 ] . More recently, the association with aggression was replicated in a study showing that maltreated children with certain alleles of MAOA were more likely to show aggressive behaviors [ 66 ] . MAOA male knockout mice also show high levels of aggression [ 67 ] . Less severe genetic variants are known to exist in MAOA which have been studied as candidates to explain various dimensions of psychiatric illness.
MAOA associations with ADHD [ 69 ] , bipolar disorder [ 70 71 72 ] panic disorder [ 73 ] and alcoholism [ 74 75 ] have been reported.
Monoamine oxidase (MAOA)
Zygosity status was determined by close inspection of physical features, birth records, parental interview and genotyping of buccal swab DNA at 6 polymorphic genetic loci: maoa, drd3, dbh, maoa, b1adr and gsalpha [ 49 50 51 52 53 ] .
MAOA shows expression primarily in neurons and preferentially catalyzes the deamination of serotonin and noradrenaline.