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Example sentences for: maoa
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The MAOA gene-linked polymorphic region (MAOA-LPR) is a 30 bp repetitive sequence that resides 1.2 kb upstream of the start codon.
Because of its metabolic role, drugs which interfere with MAOA such as clorgyline have been used to treat ADHD [ 64 ] . The most notable of MAOA polymorphism was a nonsense mutation that led to a complete loss of MAOA function in males showing extreme forms of impulsive behavior and aggression [ 65 ] . More recently, the association with aggression was replicated in a study showing that maltreated children with certain alleles of MAOA were more likely to show aggressive behaviors [ 66 ] . MAOA male knockout mice also show high levels of aggression [ 67 ] . Less severe genetic variants are known to exist in MAOA which have been studied as candidates to explain various dimensions of psychiatric illness.
Since MAOA is located on the X-chromosome, males are genetically hemizygous and females are functionally hemizygous due to random X-inactivation.
In order to assess the role of dopamine on executive attention network efficiency, it would be useful to compare the distributions of executive attention scores for these 2 polymorphisms and ask whether those individuals who are expected to have higher levels of dopamine (COMT Methionine and MAOA 3-repeat) show differences in executive attention when compared to those individuals with lower levels of dopamine.
Figure 4shows the distributions for 30 subjects who carry the (Val/Val and 4/4) genotype and 20 subjects who carry the (Met/Met and 3/3) genotypes at COMT and MAOA respectively.
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