Words similar to mao-b

Example sentences for: mao-b

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As mentioned earlier the selective and reversible inhibition of MAO-B versus that of MAO-A is the major criterion used to create the "Selectivity database" (Table 1).
Analysis of biophores #1, #2 (#4, #5) showed that both of them occur in substituted 5-[4-(benzyloxy) phenyl]-1,3,4-oxadiazol-2-(3H)-ones and their analogs (Figure 1), many of which are known to be strong MAO-B inhibitors [ 9 ] . Biophore #2 represents a flexible -CH 2 O- bridge between aryl moieties and was found to enhance the activity and selectivity of the inhibitors as shown in the original work [ 9 ] . Biophores #1 and #2 include aromatic moieties, whose main function is presumably to bind to the hydrophobic site of MAO.
Chemicals with a ratio greater than 10 were considered to be selective MAO-B inhibitors and therefore were used as "active" entries, while compounds with a ratio less than 0.1 were considered to be selective MAO-A inhibitors and thus "inactive".
In the second strategy, only the actual activity of inhibitors towards MAO-B form was considered ("Activity database").
In the "Activity database" (Table 1), inhibitors with a K i (MAO-B) value less than 1 μM were treated as "active", while compounds with a K i (MAO-B) value in the 1-5 μM range were treated as "marginally active" molecules.