Words similar to mammalian
Example sentences for: mammalian
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Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.
In multicellular mammalian organisms, a balance between cell proliferation and cell death is extremely important for the maintenance of normal healthy tissues.
The idea that TEA might be a candidate for a lead compound for the development of drugs with possible clinical applications [ 5 ] is supported by the present data that show the effectiveness of TEA in two different mammalian models of AQP1-mediated osmotic water permeability.
Although the selected Pyrococcus proteins showed more evolutionary conservation, the majority had orthologs only in other archaeal genomes, if not only in Pyrococcus . Similarly, 13 of the 16 selected mammalian proteins were either mammal-specific or vertebrate-specific (Table 2).
As discussed above, data suggest that duplication of genes encoding the TOX-like HMG-box occurred prior to mammalian radiation.