Words similar to malignancies

Example sentences for: malignancies

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In response to DNA damage induced by ionizing radiation or chemical agents such as cisplatin, ATM kinase is activated and phosphorylates a number of downstream regulatory proteins important for cell cycle arrest, growth control, apoptosis and DNA repair [ 25 26 27 28 ] . AT patients are known to be predisposed to a variety of cancers, and the fibroblasts of AT patients are hypersensitive to ionizing radiation [ 29 ] . Although many reports showed the association of ATM mutation with risk of a number of different human malignancies, including prostate cancer, breast cancer, ovarian cancer, B-cell chronic lymphocytic leukemia and mantle cell lymphoma, the underlying molecular mechanism by which ATM gene causes these changes are not well understood [ 30 31 32 33 34 35 ] . There is so far no study showing the association of ATM gene with any solid tumor.
Criteria for exclusion from the study were as follows: already known pre-existing adrenal disease or adrenalectomy, known malignancies, tuberculosis that might have involved the adrenal gland, and administration of steroids within the 3 months before the admission.
Tissue acquisition is more challenging in solid tumors than for hematopoietic malignancies, and may entail risk.
The NBs are dynamic PML-dependent depots of multiple proteins disrupted upon viral infection and in certain human malignancies [ 21, 22, 23].
Noninvasive imaging studies are commonly used during the workup of primary malignancies.