Words similar to malformations
Example sentences for: malformations
How can you use “malformations” in a sentence? Here are some example sentences to help you improve your vocabulary:
Finally, mutation of a factor required to load cohesin—the protein complex responsible for chromosome cohesion—onto chromosomes appears to cause Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder that may include facial dysmorphia, upper-extremity malformations, hirsutism, cardiac defects, growth and cognitive retardation, and gastrointestinal disorders [3,4,5].
They are among the most prevalent of congenital malformations.
Focal damage to the developing brain can have widespread consequences for structures and regions that project to or receive direct or even indirect projections from the damaged area [ 1 2 3 ] . Focal neocortical malformations induced by freeze injury to the developing cortical plate exemplify this fact.
It has been shown that these malformations, resembling human microgyria, are associated with widespread disturbances in neuronal organization [ 4 5 ] . For example, brain slices containing microgyric cortex show increased epileptogenic activity [ 6 7 8 9 ] . Microgyric anomalies are also associated with connectional alterations [ 10 11 12 ] , affecting both thalamic and cortico-cortical connectivity.
For example, the presence of neocortical malformations in certain strains of inbred mice are correlated with better performance on tasks of spatial reference memory [ 17 18 ] . On the other hand, induced microgyric animals show a variety of behavioral deficits that suggest disturbances to multiple brain systems [ 15 19 20 21 22 ] . Rapid auditory processing deficits have been found in males with induced microgyria using both an operant condition paradigm and a reflex modification paradigm [ 15 19 20 21 ] . In both paradigms, auditory processing deficits were found only on rapidly changing stimuli, and not when these same stimuli were delivered at slower rates.
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