Words similar to malformation
Example sentences for: malformation
How can you use “malformation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
Interpreting these data is, however, problematic, as a high proportion of 16°C embryos showed moderate to severe developmental malformation, making measurement of body and leg length difficult.
It is interesting to note, however, that in newborn mice a brief local application of 2 mM domoic acid to the exposed cortical surface led to a massive degeneration of AMPA/KA GluR receptor positive Cajal-Retzius neurons [ 44 ] , severe impairment of cortical neuronal migration in vivo and malformation of the domoic acid-treated neocortex [ 44 ] . Thus, because 1 mM domoic acid was clearly toxic to cerebellar granule neurons both in vitro (our current study) and in vivo [ 44 ] , we selected 1 mM domoic acid for the experiments with rat neonatal microglia reported herein.
Further, though microgyric neocortical tissue showed anomalous organization, there was no demonstrable tissue reduction localized to the malformation itself (see Figure 1).
The iris in some eyes, however, was hypoplastic and malformed (Figure 2F), and occasionally the malformation was extensive involving both iris and ciliary body.
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