Example sentences for: maladaptive

How can you use “maladaptive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Along with these structural alterations, damage to the developing brain produces functional changes [ 1 ] , suggesting that structural changes are not necessarily maladaptive in all cases.

  • Once a change in expression of the 240 genes in Table 3 have been validated, similar analyses of their putative function need to be made in order to begin to address what role the genes play in the adaptive and maladaptive response to nerve injury.

  • Several of these changes are maladaptive in the sense that they contribute to the generation of the abnormal sensations that constitute neuropathic pain, by producing ectopic spontaneous activity into the CNS, altering synaptic drive, increasing excitability and diminishing inhibitory action in the dorsal horn of the spinal cord, and by making novel synaptic contacts with inappropriate neurons [ 1 4 ] . A number of the injury-regulated genes we describe here may contribute directly to this altered sensory processing; CB1 receptor, VGF, the phospholemman ion channel, SNAP25 A, endothelin-1 and the ligand-gated 5-HT3 receptor (Table 4, see additional file 3).

  • The transcriptional changes lead both to adaptive responses, such as the capacity to survive the injury and re-grow the injured axon, and maladaptive responses that can lead to a change in sensation, including the generation of neuropathic pain [ 3 4 ] .

  • But this behavior became "maladaptive" when access to round-the-clock hamburgers and ice cream became the norm.


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