Example sentences for: malabsorption

How can you use “malabsorption” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Untreated children and adults with cystic fibrosis excrete amounts of fecal bile acids similar to patients with ileal resections [ 20 21 ] . Based on kinetic studies, this increased fecal loss appears to be secondary to an interrupted enterohepatic circulation of bile acids [ 20 21 ] . Bile acid malabsorption in cystic fibrosis appears to be due in part to diminished secretion of pancreatic enzymes and the presence of un-hydrolyzed triglycerides.

  • Supplementation with pancreatic enzymes and a low-fat diet can markedly reduce the fecal excretion of bile acids [ 9 10 20 23 ] . Other evidence, however, suggests that a diminished capacity of the ileal mucosa for bile acid uptake plays a significant role in bile acid malabsorption associated with cystic fibrosis that is independent of triglyceride concentrations.

  • found significant decreases in active bile acid uptake when examining ileal brush border membrane vesicles [ 11 ] and proposed that altered viscosity of the ileal mucus was likely not a factor in ileal bile acid malabsorption associated with cystic fibrosis.

  • However, in several studies the correlation between fecal fat excretion and fecal bile acid loss could not be demonstrated, suggesting that additional factors are responsible for bile acid malabsorption in cystic fibrosis [ 9 10 ] . In vitro studies using brush border membrane vesicles or bathed tissue samples from patients with cystic fibrosis have shown that total ileal bile acid uptake is diminished [ 11 12 ] .

  • Bile acid malabsorption in CF has been attributed to an inhibitory effect of un-hydrolyzed, intraluminal triglycerides on the intestinal absorption of bile acids.


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