Words similar to malabsorption
Example sentences for: malabsorption
How can you use “malabsorption” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast, cftr (-/-) mice may experience bile acid malabsorption even though their ileal mucosal cells express four-fold more IBAT transporters than normal cells.
They found a decrease in total (apical + basolateral) bile acid uptake compared to normal controls [ 12 ] and hypothesized that bile acid malabsorption in cystic fibrosis was due to a primary mucosal defect although they had not specifically studied apical, Na +-dependent absorption.
Untreated children and adults with cystic fibrosis excrete amounts of fecal bile acids similar to patients with ileal resections [ 20 21 ] . Based on kinetic studies, this increased fecal loss appears to be secondary to an interrupted enterohepatic circulation of bile acids [ 20 21 ] . Bile acid malabsorption in cystic fibrosis appears to be due in part to diminished secretion of pancreatic enzymes and the presence of un-hydrolyzed triglycerides.
However, in several studies the correlation between fecal fat excretion and fecal bile acid loss could not be demonstrated, suggesting that additional factors are responsible for bile acid malabsorption in cystic fibrosis [ 9 10 ] . In vitro studies using brush border membrane vesicles or bathed tissue samples from patients with cystic fibrosis have shown that total ileal bile acid uptake is diminished [ 11 12 ] .
Patients were excluded if they had active Centers for Disease Control (CDC) Class C status; could not comply with the study schedule; were in another investigational drug study; were undergoing opiate detoxification; had a malabsorption syndrome or pre-existing condition that interfered with normal gastrointestinal transit; had clinically significant laboratory abnormalities, required radiation therapy or cytotoxic chemotherapy, or had received immunomodulating agents, within 4 weeks pre-study; or had received an HIV-1 immunotherapeutic vaccine within 3 months pre-study.
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