Words similar to malabsorption
Example sentences for: malabsorption
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Untreated children and adults with cystic fibrosis excrete amounts of fecal bile acids similar to patients with ileal resections [ 20 21 ] . Based on kinetic studies, this increased fecal loss appears to be secondary to an interrupted enterohepatic circulation of bile acids [ 20 21 ] . Bile acid malabsorption in cystic fibrosis appears to be due in part to diminished secretion of pancreatic enzymes and the presence of un-hydrolyzed triglycerides.
Bile acid malabsorption in CF has been attributed to an inhibitory effect of un-hydrolyzed, intraluminal triglycerides on the intestinal absorption of bile acids.
Although generally thought to have a later presentation [ 1 ] than other primary intestinal malabsorption syndromes, recent reports of infants with SI deficiency indicate the existence of an early onset form (presentation of diarrhea at 2-16 weeks) that is complicated by severe malnutrition [ 2 ] . Starnes and Walsh [ 3 ] observed renal calculi in two adults with sucrase deficiency, but neither patient had evidence of hypercalcemia.
Supplementation with pancreatic enzymes and a low-fat diet can markedly reduce the fecal excretion of bile acids [ 9 10 20 23 ] . Other evidence, however, suggests that a diminished capacity of the ileal mucosa for bile acid uptake plays a significant role in bile acid malabsorption associated with cystic fibrosis that is independent of triglyceride concentrations.
However, in several studies the correlation between fecal fat excretion and fecal bile acid loss could not be demonstrated, suggesting that additional factors are responsible for bile acid malabsorption in cystic fibrosis [ 9 10 ] . In vitro studies using brush border membrane vesicles or bathed tissue samples from patients with cystic fibrosis have shown that total ileal bile acid uptake is diminished [ 11 12 ] .
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