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Example sentences for: maguks
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The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
1, an inwardly rectifying K +channel expressed in glial cells and also clusters it to cell membranes in vitro [ 21 ] . Thus MAGUKs may regulate the distribution and also the function of transmembrane receptors and channels.
Previously reported MAGUKs have been studied for these interactions, and elegant work has shown one of its members, p55, to form a ternary complex that links the cytoskeleton and the plasma membrane to maintain proper cell shape [ 3 ] . Also there is significant evidence that MAGUKs are active in protein clustering especially of ion channels and membrane bound receptors [ 6 ] . This interaction has been proven by experiments in which DLG5 mutants show loss of clustering of the Shaker channels at neuromuscular junction [ 6 ] . Mammalian PSD-95 is a MAGUK which binds Kir4.
The dlg-like MAGUKs do not have kinase activity [ 15 ] . Furthermore this domain has been shown to interact with other proteins [ 16 17 18 ] . MAGUKs function by binding to the transmembrane proteins at the cytoplasmic side and to other signal transduction proteins and thus appear to provide the platform for efficient and specific signal interactions between the different components of the signaling pathway.
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