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Example sentences for: maguk
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This motif helps in the binding of the MAGUK with the C-terminus of proteins that have the consensus E (S/T) × (V/l) motif [ 19 ] . However the studies on the Drosophila protein InaD, which also has a PDZ domain, show that are other targets for the PDZ domain that do not have the consensus C-terminus binding motif [ 20 ] . Thus in DLG5 the PDZ domain may be binding to other targets that do not require the classic GLGF motif for interaction.
The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
Previously reported MAGUKs have been studied for these interactions, and elegant work has shown one of its members, p55, to form a ternary complex that links the cytoskeleton and the plasma membrane to maintain proper cell shape [ 3 ] . Also there is significant evidence that MAGUKs are active in protein clustering especially of ion channels and membrane bound receptors [ 6 ] . This interaction has been proven by experiments in which DLG5 mutants show loss of clustering of the Shaker channels at neuromuscular junction [ 6 ] . Mammalian PSD-95 is a MAGUK which binds Kir4.
It is notable that the PDZ domains predicted for the DLG5 protein do not have the GLGF motif [ 2 ] , present in most members of the MAGUK family.
The MAGUK family of proteins [ 2 10 ] have characteristic domains which are present in DLG5: PDZ1 at bp 3763-4074, PDZ 2 domain 4186-4518 bp, SH3 domain bp 4570-4782 and the GUK domain at bp 4915-5539 (Figure 2).
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