Words similar to madcam-
Example sentences for: madcam-
How can you use “madcam-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Pretreatment of DETA-NONOate (100 μM) blocked the TNF-α (20 ng/ml, 12 h) induced MAdCAM-1 transcript (37.
Immune-models of colitis in mice show that the MAdCAM-1/B7 integrin bond is essential to produce colitis.
TNF-α strongly induced expression of MAdCAM-1.
MAdCAM-1 antibody reduced TK-1 adhesion to 17.
MAdCAM-1 is normally expressed in the gut, and its expression is dramatically amplified during inflammation [ 2 3 ] . The functional significance of increased appearance of MAdCAM-1 in IBD is supported by several reports which show that immunoneutralization of either MAdCAM-1 or its ligand, the α4β7 integrin, attenuate inflammation and mucosal damage in animal models of colitis [ 8 9 10 ] . However, since monoclonal antibodies directed against other ECAMs, particularly VCAM-1, can as well reduce disease activity in colitis models [ 11 12 13 14 ] , the literature suggests that MAdCAM-1 is probably necessary, but insufficient for the maximal penetrance of experimental and probably also clinical IBD.
Loading...