Words similar to macrophage-like
Example sentences for: macrophage-like
How can you use “macrophage-like” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, this agent is a potent inhibitor of microglia, the macrophage-like cells in the central nervous system [ 47 48 49 ] and shown to be effective in reducing the symptoms of experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis [ 50 ] . Together, these results suggest that this agent may be useful in preventing ocular diseases that result from oxidative stress or inflammation.
The tumor promoter phorbol myristate acetate (PMA) has been shown to activate the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase and initiate the oxidative burst response in various phagocytes, including neutrophils and the macrophage-like cell line J774A.
Murine macrophage-like cell line (J774A.
The normal intima of the synovium is one to two cells thick and consists mainly of macrophage-like and fibroblast-like cells [ 3 ] . In inflammation, macrophages make a large contribution to intimal thickening, where these cells increase in number and proportion [ 3 ] . Evidence indicates that intimal macrophages arrive via the circulation as monocytes [ 4 ] , and it is proposed that increased numbers of intimal macrophages in RA are largely attributed to enhanced monocyte recruitment from blood vessels in the synovium [ 1 5 ] . Neutrophils are also recruited in RA and can be found in abundance in synovial fluid, yet they occur in relatively low numbers in the synovium [ 5 ] . In synovial fluid their number can reach 10 6per joint, particularly during an active phase of the disease [ 6 ] . Neutrophils occur at the pannus-cartilage junction [ 7 ] and it is presumed that these cells reach the joint cavity by migrating from the blood vessels in the synovium, following a chemotactic gradient.
After three passages, these primary cultures are depleted of macrophage-like type A synoviocytes [ S3 ] . Doubling time is stable between the third and the tenth passages, but marked reduction in proliferation rate occurs in later passage cells [ S4 ] .
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