Words similar to lyn
Example sentences for: lyn
How can you use “lyn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Additionally, the sustained PLCγ2 phosphorylation induced by Btk:ER is in agreement with the idea that Btk does not activate negative regulatory pathways that turn off the signal; rather it is Lyn that is thought to be largely responsible for this aspect of BCR signaling [ 15].
These data agree both with two-hybrid experiments and in vitro filter binding assays that have demonstrated specific binding of the proline-rich region near the amino-terminus of BTK and Tec to the SH3 domains of the Src family kinases Fyn, Lyn and Hck [ 22, 25, 26].
In contrast, BCR-mediated activation of Lyn kinase was largely maintained [ 37 38 ] . The Syk-dependent signaling pathway appears to be facilitated by the adaptor molecule BLNK (also known as SLP-65 and BASH) [ 39 40 41 ] . Syk can induce the phosphorylation of BLNK in co-transfection experiments [ 42 ] , which may be important for the recruitment of other Syk substrates like PLCγ2 through a scaffolding function [ 42 ] . BLNK function is necessary for signal transduction since no Ca 2+flux or PLCγ2 phosphorylation is observed in response to BCR engagement in BLNK-deficient DT40 cells [ 43 ] .
Some of the earliest changes that occur following BCR engagement are the activation of several non-receptor protein tyrosine kinases (PTKs), including p55 blk (Blk), p59 fyn (Fyn) and p53/56 lyn (Lyn) of the Src family [ 31 ] , Btk of the Itk/Tec family [ 32 33 ] and p72 Syk (Syk) of the Syk/ZAP-70 family [ 34 ] . The importance of Syk in BCR signaling and lymphocyte development has been clearly demonstrated using gene inactivation approaches.
Thus, in a recent report ionotropic AMPA glutamate receptors were shown to " ...function not only as ion channels but also as cell-surface transducers by means of their interaction with the Src-family non-receptor protein kinase Lyn.
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