Words similar to lyn
Example sentences for: lyn
How can you use “lyn” in a sentence? Here are some example sentences to help you improve your vocabulary:
These proteins are unlikely to include Lyn or Syk, the two PTKs that are primarily responsible for the BCR-induced tyrosine phosphorylation pattern seen in DT40 whole cell lysates [ 14], since we were unable to detect phosphorylation of Lyn and Syk following specific immunoprecipitations (data not shown).
Some of the earliest changes that occur following BCR engagement are the activation of several non-receptor protein tyrosine kinases (PTKs), including p55 blk (Blk), p59 fyn (Fyn) and p53/56 lyn (Lyn) of the Src family [ 31 ] , Btk of the Itk/Tec family [ 32 33 ] and p72 Syk (Syk) of the Syk/ZAP-70 family [ 34 ] . The importance of Syk in BCR signaling and lymphocyte development has been clearly demonstrated using gene inactivation approaches.
Lyn transphosphorylates Btk within the activation loop of the kinase domain, allowing subsequent autophosphorylation of the Btk SH3 domain and full Btk activation.
Bill Kristol ( This Week ) and several Reagan aides interviewed on Meet the Press (Michael Deaver, Edwin Meese, Lyn Nofziger, and Marlin Fitzwater)--who have not read the whole thing--say Morris' book is a fiction.
In contrast, BCR-mediated activation of Lyn kinase was largely maintained [ 37 38 ] . The Syk-dependent signaling pathway appears to be facilitated by the adaptor molecule BLNK (also known as SLP-65 and BASH) [ 39 40 41 ] . Syk can induce the phosphorylation of BLNK in co-transfection experiments [ 42 ] , which may be important for the recruitment of other Syk substrates like PLCγ2 through a scaffolding function [ 42 ] . BLNK function is necessary for signal transduction since no Ca 2+flux or PLCγ2 phosphorylation is observed in response to BCR engagement in BLNK-deficient DT40 cells [ 43 ] .
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