Words similar to lymphoblasts
Example sentences for: lymphoblasts
How can you use “lymphoblasts” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mitochondria from three human cell types - lymphoblasts, fibroblasts, and neruoblastoma cells - all possessed a high affinity ThDP uptake component characterized by equivalent apparent affinity for ThDP as revealed by essentially identical K m values.
As expected, lymphoblasts derived from the TRMA patient showed no high affinity thiamine transport as revealed by thiamine uptake being the same in the absence and presence of excess unlabelled thiamine.
Although mitochondria from lymphoblasts (above) and other mammalian cells [ 13 ] were found to take up thiamine, the physiological significance of the uptake is unknown given that thiamine diphosphokinase is cytosolic and mitochondria cannot convert thiamine to ThDP [ 14 16 21 ] . We thus were interested in uptake of ThDP by mitochondria, a possibility demonstrated previously with rat liver [ 14 ] . Mitochondria from normal human lymphoblasts were able to take up ThDP in a saturable, biphasic manner (fig.
The high affinity transport of thiamine by normal lymphoblasts is abolished in the presence of a 100 fold excess of unlabeled thiamine.
TRMA is caused by mutations which destroy the high affinity thiamine transporter of the plasma membrane [ 7 8 9 10 11 12 ] . The similar K m values found for cellular and mitochondrial uptake of thiamine for normal lymphoblasts and the lack of such uptake by TRMA mitochondria and TRMA cells suggests that high affinity thiamine import into mitochondria may be carried out by the same transporter or a variant form, perhaps generated by differential splicing, of that serving on the plasma membrane.
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