Words similar to lrat
Example sentences for: lrat
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This second cysteine has been shown to be critical for a functional LRAT enzyme, suggesting that the poxviral proteins may have a related activity (see below) [ 42].
The widespread distribution of the LRAT family in eukaryotes suggests that they possessed the enzymes from an early stage in their evolution.
A search with the N1pC of E. coli (gi: 15802120, residues 35-154) recovered several P60 homologs in its first iteration, YaeF of E. coli (second iteration, E = 3 × 10 -4), the Arabidopsis homolog of LRAT, At5g16360 (gi: 15237330, second iteration, E = 5 × 10 -4) and LytN of Staphylococcus aureus (gi: 3767593, fourth iteration, 8 × 10 -6).
Interestingly, the eukaryotic versions typified by the LRAT, their viral homologs and the bacterial forms typified by E. coli YaeF, while containing all the hallmark signatures of the NlpC/P60 catalytic domain, showed a reversal in the positions of the motifs with the conserved cysteine and the conserved histidine in their primary structures (Figures 1, 2).
Reciprocal searches initiated with regions from the newly detected proteins YaeF, LRAT and LytN detected their closely related homologs in the initial iterations, but in subsequent iterations they recovered several classic N1pC/P60 homolog members with significant E-values (E < 0.01),