Words similar to lpa
Example sentences for: lpa
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In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [ 27 ] . Specifically, key protein intermediates may be physically associated with endogenous RTKs in HEK-293 cells, and therefore, down-regulation of the EGFR may negatively affect ERK phosphorylation by opioids.
This study reported significant LPA increases in cancer samples with increased intensities noted at M/Z values of 409, 433-437, 457, 481-482, 571, 599, and 619.
Lysophophatidic Acid (LPA) is a member of this class of compounds, and its plasma levels have been proposed as a potential biomarker for ovarian cancer [ 16 17 ] . LPA is a family of related molecules with molecular weights in the vicinity of 400 to 600 Daltons, and a variety of LPA species has been reported to be increased in malignant ascites from patients with ovarian cancer as detected by electrospray ionization mass spectrometry (ESI-MS) [ 18 ] . LPA related species have also been reported to be increased in plasma samples from patients with ovarian cancer using a combination of thin layer chromatography (to isolate an "LPA band" from patient plasma) followed by ESI-MS.
Another group trying to repeat the observations of increased levels of LPA associated with ovarian cancer concluded that there was no diagnostic value in the assay, and attributed the discrepant findings as possibly related to different sample centrifugation protocols used by the two groups to remove platelets from the samples prior to analysis [ 20 ] . However, LPA continues to be actively evaluated for its clinical utility [ 21 ] .
, [ 27 ] reported that endogenously-expressed LPA and endothelin-1 (ET-1) receptors in SK-N-MC cells do not activate ERKs unless the EGFR is co-expressed, although each GPCR is functional as evidenced by their ability to increase intracellular [Ca 2+].
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