Words similar to lpa
Example sentences for: lpa
How can you use “lpa” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, it is possible that in some cases they may relate to the LPA family of molecules, or to alterations in proteins that bind LPA family members.
Lysophophatidic Acid (LPA) is a member of this class of compounds, and its plasma levels have been proposed as a potential biomarker for ovarian cancer [ 16 17 ] . LPA is a family of related molecules with molecular weights in the vicinity of 400 to 600 Daltons, and a variety of LPA species has been reported to be increased in malignant ascites from patients with ovarian cancer as detected by electrospray ionization mass spectrometry (ESI-MS) [ 18 ] . LPA related species have also been reported to be increased in plasma samples from patients with ovarian cancer using a combination of thin layer chromatography (to isolate an "LPA band" from patient plasma) followed by ESI-MS.
This report also reviews the evidence that these M/Z values are consistent with LPA family members [ 19 ] . Figure 4shows the average intensities and p-values for both the cancer and control groups in the region between M/Z values of 410 to 470.
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [ 27 ] . Specifically, key protein intermediates may be physically associated with endogenous RTKs in HEK-293 cells, and therefore, down-regulation of the EGFR may negatively affect ERK phosphorylation by opioids.
This study reported significant LPA increases in cancer samples with increased intensities noted at M/Z values of 409, 433-437, 457, 481-482, 571, 599, and 619.
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