Example sentences for: low-affinity

How can you use “low-affinity” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • E. coli Mtr (high-affinity tryptophan permease) and TnaB (low-affinity tryptophan permease) comprise one distinct group, and E. coli TyrP homologs make up another distinct group.

  • For example, if the first nucleotide substrate were to bind weakly but the presence of the first bound substrate promoted efficient binding of a second substrate, then a heterodimer containing one functional and one nonfunctional active site would retain only one low-affinity binding site and be severely defective.

  • Binding involves a family of adhesins that interact with extracellular matrix components, and these adhesins have been termed microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) [ 1 ] . Specific MSCRAMMs are responsible for localization of S. aureus to particular tissues, and include fibronectin-binding proteins (FnBPs) [ 2 3 ] , fibrinogen-binding proteins [ 4 5 6 ] , elastin-binding adhesin [ 7 ] collagen-binding adhesion [ 8 ] , and a broad-specificity adhesin (MAP) that facilitates low-affinity binding of S. aureus to several proteins, including osteopontin, collagen, bone sialoprotein, fibronectin, fibrinogen, and vitronectin [ 9 ] . S. aureus can utilize MSCRAMMs to adhere directly to cells or can attach to cells through the use of bridging ligands such as Hsp60 which has an affinity for both MSCRAMMs and the β 1 -integrin host cell receptor [ 10 11 ] . Interaction of S. aureus with host cells via MSCRAMMs can induce signal transduction, tyrosine kinase activity, and cytoskeletal rearrangement [ 12 ] .

  • Recent evidence indicates that the cytokine, leukemia inhibitory factor (LIF) and its functional binding to the high affinity receptor, a heterodimer between low-affinity LIFR and glycoprotein 130 (LIFR:gp130), are players within the HPA cascade of events.

  • The UCSD–NIDCR team subsequently showed that the T1R2 and T1R3 heterodimer (a complex of one T1R2 and one T1R3 molecule) forms a broadly tuned sweet receptor, responsive to natural sugars and artificial sweeteners, and that a homodimer of two T1R3 molecules forms a low-affinity sugar receptor that responds to high concentrations of natural sugars only.


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