Words similar to low-abundance
Example sentences for: low-abundance
How can you use “low-abundance” in a sentence? Here are some example sentences to help you improve your vocabulary:
A long terminal repeat from a human endogenous retrovirus (HERV) was shown to drive the expression of an intergenic transcript from an unknown gene named HERV-HLTR associating 1 (HHLA1) and human otoconin-90 (OC90) to produce a transcript that is highly expressed in teratocarcinoma cells but not in normal human tissues or cell lines [ 33 ] . In the mouse, a Prion-like downstream gene named doppel (Dpl) was found to have an intergenic transcript that is upregulated in Prion-deficient mice [ 34 ] . The deletion of the Prion gene in these mice removes the splice acceptor site of exon 3, causing the normal Prion transcript to skip the deleted exon and inadvertently upregulate the normally low-abundance intergenic transcript by forcing it to splice more often to the doppel gene.
In a typical Affymetrix GeneChip assay, many low-abundance transcripts are present at levels below the sensitivity of detection of the array (typically about 1:100,000 mRNAs).
All metrics showed higher (worse) MEDACVs for the low-abundance Absent mRNAs than for the higher-abundance Present mRNAs (Figure 3), as expected from the presence of background noise on the arrays.
It is very important to estimate the false-positive rate for the particular experimental system being studied, and to set analysis filter criteria that lead to appropriate levels of false positives without sacrificing sensitivity to low-abundance mRNA transcripts or subtle changes in gene expression.
This may reflect in part our observation that NGF treatment increases the numbers of transcripts representing low-abundance genes [ 11 ] . Nevertheless, transcripts for ribosomal proteins remained among the most highly expressed in the NGF-treated cells.
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