Words similar to locus
Example sentences for: locus
How can you use “locus” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because the highest number of alleles was found using primer pair PM50, 24 more genotypes including one genotype from a wild species ( A. monticola ) were used to search more alleles at this particular locus.
FEOM3 locus (see Additional File 2).
Atrial fibrillation segregates as an autosomal dominant disease characterized by atrial fibrillation on an electrocardiogram [ 1 ] . We diagnosed atrial fibrillation in five families from Spain in which the arrhythmia was the primary manifestation and not associated with any gross cardiac or metabolic abnormality [ 1 ] . Genetic linkage analysis was performed and the locus responsible for atrial fibrillation in our family was mapped to 10q22 between markers D101786 and D10S1630, an area of about 11 cM [ 1 ] . We proceeded with the candidate gene approach and DLG5 was on of the genes mapped to the critical region between the flanking markers [ 2 ] . This gene belongs to the MAGUK (Membrane Associated Gyanylate Kinase) family of proteins known to form scaffolds for proteins involved in intracellular signal transduction [ 2 ] . The MAGUK family of proteins has been extensively studied in recent years and shown to play a role in the formation of cell junctions, maintenance of cell shape, [ 3 4 5 ] and clustering of channel proteins at the cell surface [ 6 7 8 ] . Given its location in our critical region and its function it was selected as a candidate for atrial fibrillation.
Introduction of single copy transgenes into the hydroxyphosphoribosyl transferase (HPRT) locus has been previously described by Bronson et al . This approach successfully overcomes the problems associated with the integration of variable copy numbers of transgenes into random genomic locations.
As a first step in characterizing the molecular nature of the T Wis allele of T , the exact identity of the ETn element inserted into the locus was determined.
Loading...