Words similar to locus
Example sentences for: locus
How can you use “locus” in a sentence? Here are some example sentences to help you improve your vocabulary:
Quality control assays demonstrating that whole genome amplification was successful were performed for locus 979 and 1004 as described [ 10 ] , and amplified DNA was used directly in genotyping reactions at the same concentration as the original genomic DNA, typically 200 ng/reaction.
These correctly targeted ES cell clones were called Hnf3αloxPNeo clones 1-4 to indicate that a pgkloxP-Neo cassette had been introduced into the Hnf3 α locus.
The trans-silencers as well as their targets reside in single-copy, gene-rich regions that are only sparsely populated with repetitive or transposable elements, features that have been shown to mediate epigenetic activity in other cases [ 18 31 32 ] . Therefore trans-silencing of GFP-COP1 is probably not mediated by transgene flanking sequences [ 27 ] . In contrast, as with other genes cited above, trans-silencing ability is correlated with transgene locus structure, given that the C73 and C97 trans-silencers contain multiple T-DNAs while their targets, E82 and L91, are essentially dimeric and monomeric, respectively.
Two-point linkage in the presence of locus heterogeneity was assessed by the admixture test of Ott, using HOMOG [ 36 ] . We used a heterogeneity LOD (HLOD) of > 1.3 to indicate nominal evidence for linkage for all linkage analyses [ 37 ] .
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
Loading...